+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Serum penicillin concentrations after intramuscular administration of benzathine penicillin G in children with rheumatic fever and controls



Serum penicillin concentrations after intramuscular administration of benzathine penicillin G in children with rheumatic fever and controls



Journal of Investigational Allergology and Clinical Immunology 2(5): 268-273



Serum and urine penicillin levels were determined in 11 children with rheumatic fever (RF) who were receiving benzathine penicillin G (BPG) prophylactically every 3 weeks and in 10 children without RF who received the drug for the treatment of other infections. The dose given was 600,000 units for children weighing less than 25 kg and 1,200,000 units for those with a weight above 25 kg. Blood and urine samples were collected from both groups before and on days 7, 14 and 21 after BPG administration. Our results showed that: minimum inhibitory concentrations (MICs) of BPG for group A beta-hemolytic streptococci were 0.02 IU/ml or 0.0125 microgram/ml; intramuscular BPG did not give adequate serum levels to block the growth of group A beta-hemolytic streptococci in approximately 24 and 62% of children included in the study on days 14 and 21 after its administration, respectively; BPG metabolism was similar in both groups and did not depend on the underlying disease; serum and urine levels did not vary according to sex and weight; and there was a small correlation between serum and urine levels.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 009406268

Download citation: RISBibTeXText

PMID: 1342909


Related references

Penicillin g benzathine levels in serum and urine after intramuscular administration to children with rheumatic fever and controls. Journal of Rheumatology 19(Suppl. 33): 114, 1992

Serum penicillin concentrations after intramuscular administration of benzathine penicillin G in children. Pediatrics 69(4): 452-454, 1982

Concentration of penicillin in the serum following intramuscullar administration of benzathine penicillin G to children with inactive rheumatic fever. Pediatrics 21(2): 233-242, 1958

Penicillin concentrations in sera and tonsils after intramuscular administration of benzathine penicillin G to children. Pediatric Infectious Disease Journal 22(12): 1075-1078, 2003

Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever. Antimicrobial Agents and ChemoTherapy 38(5): 1203-1204, 1994

Factors associated with loss of penicillin G concentrations in serum after intramuscular benzathine penicillin G injection: a meta-analysis. Pediatric Infectious Disease Journal 31(7): 722-725, 2012

Body fluid concentrations of penicillin following intramuscular injection of single doses of benzathine penicillin G and/or procaine penicillin G. Antibiotic Medicine & Clinical Therapy 6(4): 232-241, 1959

Serum concentrations of penicillin after intramuscular administration of procaine, benzyl, and benethamine penicillin in children with pneumonia. Journal of Pediatrics 110(2): 299-302, 1987

Serum concentration of penicillin in the horse after repeated intramuscular injections of procaine penicillin G alone or in combination with benzathine penicillin and/or phenylbutazone. American Journal of Veterinary Research 45(5): 1003-1007, 1984

Serial serum penicillin levels following an injection of benzathine penicillin (12 lakh units) in children of rheumatic heart disease. Indian Journal of Pediatrics 53(1): 99, 1986

Serum levels of penicillin and their variations after administration of benzathine penicillin in children. British Journal of Venereal Diseases 37: 252-256, 1961

A comparison of oral and intramuscular benzathine penicillin G for the prevention of streptococcal infections and recurrences of rheumatic fever. Pediatrics 19(2): 201-207, 1957

Long-term prognosis of rheumatic fever patients receiving regular intramuscular benzathine penicillin. Circulation 45(3): 543-551, 1972

Disposition of penicillin G after administration of benzathine penicillin G, or a combination of benzathine penicillin G and procaine penicillin G in cattle. American Journal of Veterinary Research 55(6): 825-830, 1994