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Sibling allogeneic bone marrow transplantation in a patient with type I Glanzmann's thrombasthenia



Sibling allogeneic bone marrow transplantation in a patient with type I Glanzmann's thrombasthenia



British Journal of Haematology 99(1): 58-60



Glanzmann's thrombasthenia is a rare inherited bleeding disorder caused by either quantitative or qualitative abnormalities of the platelet membrane glycoprotein (Gp) IIb/IIIa complex. Bleeding is usually mucocutaneous in origin and may be of a severe nature. We report the use of allegeneic bone marrow transplantation in a 5-year-old child with homozygous type I Glanzmann's thrombasthenia, using the patient's younger brother as marrow donor. Engraftment was successful and has resulted in a resolution of bleeding episodes. We conclude that allogeneic BMT is a potentially curative option for those with Glanzmann's thrombasthenia associated with severe bleeding symptoms.

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Accession: 009414073

Download citation: RISBibTeXText

PMID: 9359503

DOI: 10.1046/j.1365-2141.1997.3533167.x



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