+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Sibling allogeneic bone marrow transplantation in a patient with type I Glanzmann's thrombasthenia

Sibling allogeneic bone marrow transplantation in a patient with type I Glanzmann's thrombasthenia

British Journal of Haematology 99(1): 58-60

Glanzmann's thrombasthenia is a rare inherited bleeding disorder caused by either quantitative or qualitative abnormalities of the platelet membrane glycoprotein (Gp) IIb/IIIa complex. Bleeding is usually mucocutaneous in origin and may be of a severe nature. We report the use of allegeneic bone marrow transplantation in a 5-year-old child with homozygous type I Glanzmann's thrombasthenia, using the patient's younger brother as marrow donor. Engraftment was successful and has resulted in a resolution of bleeding episodes. We conclude that allogeneic BMT is a potentially curative option for those with Glanzmann's thrombasthenia associated with severe bleeding symptoms.

(PDF emailed within 0-6 h: $19.90)

Accession: 009414073

Download citation: RISBibTeXText

PMID: 9359503

DOI: 10.1046/j.1365-2141.1997.3533167.x

Related references

Complete correction of Glanzmann's thrombasthenia by allogeneic bone-marrow transplantation. British Journal of Haematology 59(4): 635-641, 1985

Correction of a large animal model of type I Glanzmann's thrombasthenia by nonmyeloablative bone marrow transplantation. Experimental Hematology 31(12): 1357-1362, 2003

Bone marrow transplantation for Glanzmann's thrombasthenia. Bone Marrow Transplantation 14(1): 147-150, 1994

Successful Nonmyeloablative Allogeneic Bone Marrow Transplantation for Donor-Derived De Novo Adult T-Cell Leukemia after Myeloablative Allogeneic Bone Marrow Transplantation from HTLV-I Positive Sibling Case Report. Blood 100(11): Abstract No 5379, November 16, 2002

Glanzmann thrombasthenia with acute myeloid leukemia successfully treated by bone marrow transplantation. International Journal of Hematology 81(1): 77-80, 2005

Secondary eosinophilia in a patient with hypereosinophilic syndrome after allogeneic bone marrow transplantation from a sibling donor. Japanese Journal of Clinical Hematology 42(6): 496-501, 2001

Severe acquired aplastic anemia: historical outcome of patients treated by allogeneic bone marrow transplantation from matched sibling donors. A study by the Spanish Group for Bone Marrow Transplantation in Children (GETMON). Anales de Pediatria 69(1): 5-9, 2008

Human herpesvirus 6 meningoencephalitis successfully treated with ganciclovir in a patient who underwent allogeneic bone marrow transplantation from an HLA-identical sibling. International Journal of Hematology 75(4): 421-425, 2002

Allogeneic stem cell transplantation for Glanzmann thrombasthenia. Pediatric Blood & Cancer 52(5): 682-683, 2009

Indication for allogeneic stem cell transplantation in Glanzmann's thrombasthenia. Hamostaseologie 33(4): 305-312, 2014

An update of prognostic factors for allogeneic bone marrow transplantation in multiple myeloma using matched sibling donors. European Group for Blood and Marrow Transplantation. Stem Cells 13 Suppl 2: 122-125, 1995

Use of allogeneic stem cell transplantation for moderate-severe Glanzmann thrombasthenia. Platelets 26(7): 702-704, 2016

Treatment of severe thrombasthenia combined with pyknodysostosis by allogeneic bone marrow transplantation. Onkologie 14(SUPPL 2): 153, 1991