+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Simultaneous determination of trimipramine and desmethyl- and hydroxytrimipramine in plasma and red blood cells by capillary gas chromatography with nitrogen-selective detection



Simultaneous determination of trimipramine and desmethyl- and hydroxytrimipramine in plasma and red blood cells by capillary gas chromatography with nitrogen-selective detection



Journal of Chromatography Biomedical Applications 613(1): 59-65



A simple procedure is described that permits the simultaneous determination of trimipramine and its two major metabolites, desmethyl- and hydroxytrimipramine, in human plasma or red blood cells (RBCs) at therapeutic concentrations. The extracted biological fluids are injected into a capillary gas chromatograph with an OV-1-fused-silica column coupled to a nitrogen-phosphorus-selective detector. The limit of determination for trimipramine is 3 ng/ml and for that desmethyl- and hydroxytrimipramine is 4 ng/ml. The method permits the RBC/plasma ratios to be determined and to be correlated with the clinical response.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009419659

Download citation: RISBibTeXText

PMID: 8458903

DOI: 10.1016/0378-4347(93)80197-c


Related references

Simultaneous determination of clomipramine and its N-desmethyl metabolite in human whole blood by capillary gas chromatography with mass-selective detection. Journal of Chromatography 428(1): 71-80, 1988

A comparative solid-phase extraction study for the simultaneous determination of fluoxetine, amitriptyline, nortriptyline, trimipramine, maprotiline, clomipramine, and trazodone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection. Journal of Analytical Toxicology 27(6): 353-358, 2003

Simultaneous determination of norethisterone and six metabolites in human plasma by capillary gas chromatography with mass-selective detection. Journal of Chromatography B Biomedical Applications 674(2): 155-165, 1995

Determination of cyclobenzaprine in plasma and urine using capillary gas chromatography with nitrogen-selective detection. Journal of Chromatography 339(2): 414-418, 1985

Determination of bupivacaine in human plasma by capillary gas chromatography with nitrogen-selective detection. Journal of Chromatography 383(1): 232-235, 1986

Simultaneous determination of nicotine and cotinine in plasma using capillary column gas chromatography with nitrogen-sensitive detection. Journal of Chromatography 232(2): 283-293, 1982

Simultaneous determination of nicotine and cotinine in plasma by capillary gas liquid chromatography with nitrogen sensitive detection. Fresenius Zeitschrift fuer Analytische Chemie 333(7): 745-746, 1989

Simultaneous determination of imipramine and its metabolite desipramine in human plasma by capillary gas chromatography with mass-selective detection. Journal of Chromatography. B Biomedical Sciences and Applications 703(1-2): 147-158, 1997

Simultaneous determination of imipramine and its metabolite desipramine in human plasma by capillary gas chromatography with mass-selective detection. Journal of Chromatography B 703(1-2): 147-158, 1997

Simultaneous determination of the prodrug zofenopril and its active drug in plasma by capillary gas chromatography-mass-selective detection. Journal of Chromatography 428(1): 81-92, 1988

Automated determination of trimipramine and N-desmethyl-trimipramine in human plasma or serum by HPLC with on-line solid phase extraction. Journal of Liquid Chromatography 18(17): 3495-3505, 1995

Determination of carbisocaine, heptacaine and pentacaine in plasma by capillary gas chromatography with nitrogen-selective detection. Journal of Pharmaceutical and Biomedical Analysis 4(3): 333-340, 1986

Determination of plasma phenytoin by capillary gas chromatography with nitrogen-phosphorus detection and with selective ion monitoring. Journal of Chromatography 310(1): 199-203, 1984

Determination of oxpentifylline and three metabolites in plasma by automated capillary gas chromatography using nitrogen-selective detection. Journal of Chromatography 423: 139-146, 1987

Determination of a cytostatic agent, bendamustine, in plasma using capillary gas chromatography with nitrogen-selective detection. Journal of Chromatography 525(2): 459-463, 1990