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Single intraoperative application versus postoperative mitomycin C eye drops in pterygium surgery



Single intraoperative application versus postoperative mitomycin C eye drops in pterygium surgery



Ophthalmology 102(12): 1949-1952



Purpose: To determine the minimum effective dosage, most effective route of administration and long-term effects of mitomycin C for prevention of recurrence after pterygium surgery. Methods: In a prospective, masked study, 227 patients undergoing surgery for primary pterygia were assigned randomly to five groups: group 1 received a single intraoperative application of 0.2 mg/ml mitomycin C for 3 minutes; group 2 received a single intraoperative application of 0.4 mg/ml mitomycin C for 3 minutes; group 3 received mitomycin C eye drops 0.2 mg/ml three times daily for 7 days; group 4 received mitomycin C eye drops 0.4 mg/ml three times daily for 14 days; group 5 acted as a control (surgery alone). Results: After a mean follow-up time of 28 months recurrence rates of 6.66%, 4.08%, 4.26%, 4.44%, and 29.27%, respectively, were observed. Statistical analysis showed significant differences between groups receiving mitomycin C and the control (P ltoreq 0.001). There was no statistical difference among treated groups (P gtoreq 0.0681). No complications of therapy were observed. Conclusion: These results support the efficacy and relatively safety of a single, low concentration, intraoperative application of mitomycin C in pterygium surgery together with the use of a conjunctival flap, avoiding excessive cauterization of the sclera and leaving bare sclera.

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Accession: 009421011

Download citation: RISBibTeXText

PMID: 9098301

DOI: 10.1016/s0161-6420(95)30770-1


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