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Solid State Phosphorus-31 Magnetic Resonance Imaging of Bone Mineral


Solid State Phosphorus-31 Magnetic Resonance Imaging of Bone Mineral



Magnetic Resonance in Medicine 33(3): 293-299



ISSN/ISBN: 0740-3194

PMID: 7760697

DOI: 10.1002/mrm.1910330303

Chemically selective solid state phosphorus-31 nuclear magnetic resonance (NMR) imaging of the mineral phase of bone and synthetic calcium phosphate models for bone mineral is demonstrated with microscopy-scale (about 5 mm field of view) apparatus at 6.0 T magnetic field strength. Pixel-by-pixel linear combination of image data from multiple radio frequency (RF) pulse sequences, chosen to develop contrast between chemical constituents of interest in the mineral, generates derived images showing the distribution of individual constituents. The technique combines the noninvasive character of magnetic resonance imaging (MRI) with the ability of solid state NMR spectroscopy to characterize subtle chemical variations in bone mineral, as well as to measure the amount of mineral. These methods are, in principle, extensible to larger dimensional scales suitable for live animal subjects or human limbs.

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Accession: 009430634

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