Section 10
Chapter 9,444

Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression

Dawson, S.R.; Turner, D.L.; Weintraub, H.; Parkhurst, S.M.

Molecular and Cellular Biology 15(12): 6923-6931


ISSN/ISBN: 0270-7306
PMID: 8524259
DOI: 10.1128/mcb.15.12.6923
Accession: 009443447

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The Hairy/Enhancer of split/Deadpan family of basic helix-loop-helix (bHLH) proteins function as transcriptional repressors. We have examined the mechanisms of repression used by the Hairy and E(SPL) proteins by assaying the antagonism between wild-type or altered Hairy/E(SPL) and Scute bHLH proteins during sex determination in Drosophila melanogaster.

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