Home
  >  
Section 10
  >  
Chapter 9,444

Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression

Dawson, S.R.; Turner, D.L.; Weintraub, H.; Parkhurst, S.M.

Molecular and Cellular Biology 15(12): 6923-6931

1995

ISSN/ISBN: 0270-7306
PMID: 8524259
DOI: 10.1128/mcb.15.12.6923
Accession: 009443447
Download citation:  
Text
  |  
BibTeX
  |  
RIS
The Hairy/Enhancer of split/Deadpan family of basic helix-loop-helix (bHLH) proteins function as transcriptional repressors. We have examined the mechanisms of repression used by the Hairy and E(SPL) proteins by assaying the antagonism between wild-type or altered Hairy/E(SPL) and Scute bHLH proteins during sex determination in Drosophila melanogaster.

PDF emailed within 0-6 h: $19.90




Related References

Hamamori, Y.; Wu, H.Y.; Sartorelli, V.; Kedes, L. 1997: The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist Molecular and Cellular Biology 17(11): 6563-6573
Hou, X. J.; Li, J. M.; Liu, B. L.; Wei, L. 2017: Co-expression of basic helix-loop-helix protein (bHLH) and transcriptional activator-Myb genes induced anthocyanin biosynthesis in hairy root culture of Nicotiana tabacum L and Ipomea tricolor Acta Physiologiae Plantarum 39(2): 59
Jiang, L.; Crews, S.T. 2003: The Drosophila dysfusion basic helix-loop-helix (bHLH)-PAS gene controls tracheal fusion and levels of the trachealess bHLH-PAS protein Molecular and Cellular Biology 23(16): 5625-5637
Popovic, M.; Wienk, H.; Coglievina, M.; Boelens, R.; Pongor, S.án.; Pintar, A. 2014: The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA Proteins 82(4): 537-545
Pollenz, R.S.; Sullivan, H.R.; Holmes, J.; Necela, B.; Peterson, R.E. 1996: Isolation and expression of cDNAs from rainbow trout (Oncorhynchus mykiss) that encode two novel basic helix-loop-Helix/PER-ARNT-SIM (bHLH/PAS) proteins with distinct functions in the presence of the aryl hydrocarbon receptor. Evidence for alternative mRNA splicing and dominant negative activity in the bHLH/PAS family Journal of Biological Chemistry 271(48): 30886-30896
Ejarque, M.; Altirriba, J.; Gomis, R.; Gasa, R. 2013: Characterization of the transcriptional activity of the basic helix-loop-helix (bHLH) transcription factor Atoh8 Biochimica et Biophysica Acta 1829(11): 1175-1183
Kang, H.; Oh, E.; Choi, G.; Lee, D. 2010: Genome-wide DNA-binding specificity of PIL5, an Arabidopsis basic Helix-Loop-Helix (bHLH) transcription factor International Journal of Data Mining and Bioinformatics 4(5): 588-599
Ohkawara, T.; Shintani, T.; Saegusa, C.; Yuasa-Kawada, J.; Takahashi, M.; Noda, M. 2004: A novel basic helix-loop-helix (bHLH) transcriptional repressor, NeuroAB, expressed in bipolar and amacrine cells in the chick retina Brain Research. Molecular Brain Research 128(1): 58-74
Kabir, N.N.; Rönnstrand, L.; Kazi, J.U. 2013: The basic helix-loop-helix (bHLH) proteins in breast cancer progression Medical Oncology 30(3): 666
Knöfler, M.; Meinhardt, G.; Bauer, S.; Loregger, T.; Vasicek, R.; Bloor, D.J.; Kimber, S.J.; Husslein, P. 2002: Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains Biochemical Journal 361(Pt 3): 641-651
Centonze, V.E..; Firulli, B.A..; Firulli, A.B.. 2004: Fluorescence Resonance Energy Transfer (FRET) as a method to calculate the dimerization strength of basic Helix-Loop-Helix (bHLH) proteins Biological Procedures Online 6: 78-82
Johnson, J.D.; Zhang, W.; Rudnick, A.; Rutter, W.J.; German, M.S. 1997: Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity Molecular and Cellular Biology 17(7): 3488-3496
Sharma, P.; Chinaranagari, S.; Chaudhary, J. 2015: Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity Biochimie 112: 139-150
Fisher, A.L.; Ohsako, S.; Caudy, M. 1996: The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain Molecular and Cellular Biology 16(6): 2670-2677
Jennings, B.H.; Tyler, D.M.; Bray, S.J. 1999: Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins Molecular and Cellular Biology 19(7): 4600-4610
Karandikar, U.C.; Shaffer, J.; Bishop, C.P.; Bidwai, A.P. 2005: Drosophila CK2 phosphorylates Deadpan, a member of the HES family of basic-helix-loop-helix (bHLH) repressors Molecular and Cellular Biochemistry 274(1-2): 133-139
Wang, Z.; Atchley, W.R. 2007: Spectral analysis of sequence variability in basic-helix-loop-helix (bHLH) protein domains Evolutionary Bioinformatics Online 2: 187-196
Niu, X.; Guan, Y.; Chen, S.; Li, H. 2017: Genome-wide analysis of basic helix-loop-helix (bHLH) transcription factors in Brachypodium distachyon Bmc Genomics 18(1): 619
Zhang, T.; Lv, W.; Zhang, H.; Ma, L.; Li, P.; Ge, L.; Li, G. 2018: Genome-wide analysis of the basic Helix-Loop-Helix (bHLH) transcription factor family in maize Bmc Plant Biology 18(1): 235
Hao, Y.; Zong, X.; Ren, P.; Qian, Y.; Fu, A. 2021: Basic Helix-Loop-Helix (bHLH) Transcription Factors Regulate a Wide Range of Functions in Arabidopsis International Journal of Molecular Sciences 22(13)