Stereoselective synthesis of dolastatin 10 and its congeners
Shioiri, T.; Hayashi, K.; Hamada, Y.
Tetrahedron 49(9): 1913-1924
1993
ISSN/ISBN: 0040-4020
DOI: 10.1016/s0040-4020(01)80547-0
Accession: 009456391
Efficient synthesis of dolastatin 10 (1), a potent antitumor peptide from a sea hare Dolabella auricularia, has been achieved in a stereoselective manner. Trisnordolastatin 10 (2) and its C-9-epimer (3) have also been synthesized.
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