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Chapter 9,458

Sterol regulation of acetyl coenzyme A carboxylase: A mechanism for coordinate control of cellular lipid

Lopez, J.M.; Bennett, M.K.; Sanchez, H.B.; Rosenfeld, J.M.; Osborne, T.F.

Proceedings of the National Academy of Sciences of the United States of America 93(3): 1049-1053

1996


ISSN/ISBN: 0027-8424
PMID: 8577712
DOI: 10.2307/38745
Accession: 009457536

Transcription from the housekeeping promoter for the acetyl coenzyme A carboxylase (ACC) gene, which encodes the rate-controlling enzyme of fatty acid biosynthesis, is shown to be regulated by cellular sterol levels through novel binding sites for the sterol-sensitive sterol regulatory element binding protein (SREBP)-1 transcription factor. The position of the SREBP sites relative to those for the ubiquitous auxiliary transcription factor Sp1 is reminiscent of that previously described for the sterol-regulated low density lipoprotein receptor promoter. The experiments provide molecular evidence that the metabolism of fatty acids and cholesterol, two different classes of essential cellular lipids, are coordinately regulated by cellular lipid levels.

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