Stimulatory effect of synthetic luminal cholecystokinin releasing factor (LCRF) fragment (1-35) on pancreatic exocrine secretion in conscious rats

Miyasaka, K.; Funakoshi, A.

Pancreas 15(3): 310-313

1997


ISSN/ISBN: 0885-3177
PMID: 9336797
DOI: 10.1097/00006676-199710000-00015
Accession: 009459458

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Abstract
The effects of a synthetic putative luminal cholecystokinin (CCK) releasing factor (LCRF) fragment (1-35) on pancreatic exocrine secretion were examined in conscious Wistar rats and a mutant strain of rats lacking the CCK-A receptor. Intraduodenal injection of graded doses of the LCRF fragment induced biphasic responses in Wistar rats. The injection of 0.1 mug of the LCRF fragment produced a maximal response, while 1 mug produced a lower response. No significant effect was observed in rats lacking the CCK-A receptor. The synthetic LCRF fragment stimulated pancreatic secretion via CCK-A receptors in conscious rats.