Structural elucidation of the novel type VII group B Streptococcus capsular polysaccharide by high resolution NMR spectroscopy

Kogan, G.; Brisson, J.R.; Kasper, D.L.; von Hunolstein, C.; Orefici, G.; Jennings, H.J.

Carbohydrate Research 277(1): 1-9


ISSN/ISBN: 0008-6215
PMID: 8548782
DOI: 10.1016/0008-6215(95)00195-y
Accession: 009465671

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The type VII capsular polysaccharide isolated from the newly discovered group B Streptococcus (GBS) strain contains D-glucose, D-galactose, N-acetyl-D-glucosamine and N-acetylneuraminic acid in the molar ratio 2:2:1:1. High-resolution one- and two-dimensional (1D and 2D) 1H and 13C NMR spectroscopy of the native and desialylated polysaccharides showed the type VII GBS capsular polysaccharide to contain the following branched hexasaccharide repeating unit: [formula: see text] Despite extensive structural similarity with the previously described GBS polysaccharides, the type VII polysaccharide showed no cross-reaction with the heterologous antisera.