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Studies on radio-opaque polymeric biomaterials with potential applications to endovascular prostheses


, : Studies on radio-opaque polymeric biomaterials with potential applications to endovascular prostheses. Biomaterials 17(18): 1803-1812

A new polymeric biomaterial, which uniquely combines radio-opacity (X-ray visibility) and low thrombogenicity, is described. First, preparation, purification, and identification of the essential monomeric building block, 2-(2'-iodobenzoyl)-ethyl methacrylate (3), are outlined. Second, the synthesis of the biomaterial, a terpolymer with composition MMA: HEMA: 3 = 65:15:20 (mole/mole/mole) is described. Third, the physico-chemical characteristics of the polymer (e.g. NMR spectroscopy, thermal behaviour) are given. Fourth, the in vitro thrombogenicity of the material was characterized by means of recent test assay. The combined results reveal that the terpolymer is very suitable for prosthetic applications in the cardiovascular system. A new prototype of an endovascular stent, made from the terpolymer, is presented. Stents find clinical use in interventional cardiology, in conjunction with percutaneous transluminal coronary angioplasty (PTCA). It is put forward that the stent prototype presented herein has, at least in principle, some advantages over existing (metallic) stents; these advantages are primarily owing to the unique combination of X-ray visibility and haemocompatibility which is presently achieved.

Accession: 009474957

PMID: 8879520

DOI: 10.1016/0142-9612(95)00339-8

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Wooldridge, T.; Bailey, C., 1982: Euryhaline zooplankton of the Sundays Estuary and notes on trophic relationships. The euryhaline component of the zooplankton in the Sundays River estuary was sampled monthly at 10 stations from Aug., 1979-April, 1981. In deeper regions surface and near-bottom samples were taken (stations 1-7) using WP2 nets. Shallow (>...

Garnier J. M.; Fontes J. C., 1981: Hydrochemistry, geochemistry of the isotopes of the environment, and conditions of circulation in a confined aquifer of Astian sands, Herault. Bulletin du Bureau de Recherches Geologiques et Minieres Section 3: Hydrologie, Geologie de l'Ingenieur

Kibenge, M.T.; Chan, C.B., 2002: The effects of high-fat diet on exercise-induced changes in metabolic parameters in Zucker fa/fa rats. The objectives of this study were to document the effects of moderate aerobic exercise on insulin secretion and other metabolic indices in fa/fa rats and to determine if a high-fat (HF) diet altered these effects. Six-week-old fa/fa and lean Zucke...

Modell B., 1991: Social and genetic implications of customary consanguineous marriage among british pakistanis report of a meeting held at the ciba foundation january 15 1991. Journal of Medical Genetics 28(10): 720-723

Minagawa, Jun; Crofts, Antony, R., 1994: A robust protocol for site-directed mutagenesis of the D1 protein in Chlamydomonas reinhardtii: A PCR-spliced psbA gene in a plasmid conferring spectinomycin resistance was introduced into a psbA deletion strain. In this paper, we describe a protocol to obtain a site-directed mutants in the psbA gene of Chlamydomonas reinhardtii, which overcomes several drawbacks of previous protocols, and makes it possible to generate a mutant within a month. Since the la...

H. -R. Wenk; W. R. Wilde, 1973: Chemical anomalies of Lunar Plagioclase, Described by Substitution Vectors and Their Relation to Optical and Structural Properties. Lunar plagioclase posed an enigma because optical properties indicate slow cooling while structural properties suggest rapid quenching when compared directly to terrestrial plagioclase. If, however, the An-content is inferred from the Al/Si ratio...

Abstracts., 1981: Fourth Meeting of the American Society of Primatologists, June 2-5, 1981, San Antonio, Texas. Sessions and Abstracts. American Journal of Primatology, 13: 307-365

Fritz, Robert, 2004: Phosphatidylserine-containing muscle development diet supplement and anti-catabolic dietary nutrients. An anti-catabolic dietary supplement, phosphatidylserine, and diet and exercise programs using phosphatidylserine for lean muscle development and optimized conditioning.

Marinari, L.R.; Berkenkopf, J.W.; Weichman, B.M., 1991: Characterization of phospholipase A2 activity in rat RPAR-induced pleurisy. At 10 min, 2 h and 4 h after induction of a reverse passive Arthus reaction (RPAR) in the pleural cavity of rats, pleural exudate was collected and analyzed in vitro for phospholipase A2 (PLA2) acyl hydrolytic activity. Inasmuch as exudate PLA2 wa...

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