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Study on the dependence potential of (+)-5-oxo-D-prolinepiperidinamide monohydrate (NS-105) in rhesus monkeys and rats


, : Study on the dependence potential of (+)-5-oxo-D-prolinepiperidinamide monohydrate (NS-105) in rhesus monkeys and rats. Oyo Yakuri 55(2-3): 61-69

The dependence potential of (+)-5-OXO-D-prolinepiperidinamide monohydrate (NS-105) was assessed by four experiments in rhesus monkeys and rats. In gross behavioral observation for acute CNS effects with intravenous administration of NS-105 up to 128 mg/kg in 3 monkeys per dose, no specific effects were observed. In intravenous self-administration of NS-105 at 1, 4 and 16 mg/kg/infusion in 4 monkeys, no active intake was observed.

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