+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Superior effect of tazobactam/piperacillin compared to piperacillin on beta-lactamase-producing Pseudomonas aeruginosa

Superior effect of tazobactam/piperacillin compared to piperacillin on beta-lactamase-producing Pseudomonas aeruginosa

ChemoTherapy 43(3): 171-178

To evaluate the synergistic antimicrobial effects of tazobactam (TAZ), a beta-lactamase inhibitor, and piperacillin (PIPC) on Pseudomonas aeuruginosa, we compared the antimicrobial effects of TAZ/PIPC with those of PIPC alone on bacteria inducibly or constitutively producing beta-lactamase. TAZ/PIPC had more potent antimicrobial effects compared with PIPC on clinical isolates producing beta-lactamase. In the treatment of mouse systemic infection, the therapeutic effect of PIPC was markedly decreased by beta-lactamase, but that of TAZ/PIPC was only slightly decreased. In the treatment of local infections in mice, the therapeutic effects of PIPC were decreased due to the induction of beta-lactamase and the emergence of bacterial strains constitutively producing beta-lactamase, while those of TAZ/PIPC were not affected.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 009490412

Download citation: RISBibTeXText

PMID: 9142457

Related references

Susceptibilities of 55 Strains of Neisseria meningitides Isolated in Spain in 1993 and 1994. Chemotherapy 43(3): 168-170, 1997

Pharmacokinetic Profile of the Anti-Sickling Hydroxyurea in Wild-Type and Transgenic Sickle Cell Mice. Chemotherapy 47(4): 270-278, 2001

Piperacillin plus aztreonam for treatment of neutropenic fever. Pediatrics International 45(3): 307-310, 2003

In vitro synergy of pseudolaric acid B and fluconazole against clinical isolates of Candida albicans. Mycoses 54(5): E400-E406, 2011

Synergistic effect of heartwood extractives and quaternary ammonium compounds on termite resistance of treated wood. Pest management science 63(1): 90-95, 2007

Comparative in-vitro activity of new quinolones against clinical isolates and resistant mutants. Journal of Antimicrobial ChemoTherapy 29(1): 41-48, 1992

Tazobactam is a potent inactivator of selected inhibitor-resistant class A beta-lactamases. Fems Microbiology Letters 148(1): 59-62, 1997

Activity of photosystem II in water stressed Triticum aestivum. Plant Physiology (Rockville) 105(1 Suppl. ): 107, 1994

Serum bactericidal activity of gemifloxacin versus clarithromycin against Streptococcus pneumoniae with different susceptibility to quinolones. Journal of ChemoTherapy 16(1): 56-61, 2004

Piper cubeba targets multiple aspects of the androgen-signalling pathway. A potential phytotherapy against prostate cancer growth?. 2008

In vitro activity of syncytiotrophoblast from human term placenta: hormonal determinations. Israel Journal of Medical Sciences 12(1): 82-82, 1976

Effect of applying the new Clinical and Laboratory Standards Institute ceftazidime and ceftriaxone susceptibility breakpoints for Escherichia coli in Hong Kong. International Journal of Antimicrobial Agents 37(3): 270-271, 2011

In vitro susceptibility of paediatric clinical isolates of Candida albicans to fluconazole and voriconazole. Mycoses 44(Suppl. 1): 52, 2001

Accuracy of asthma information on the world wide web. Journal for Specialists in Pediatric Nursing 15(3): 211-216, 2010

Comparison of Vitek 32 and Microlog ML3 systems for identification of select biological warfare agents. Abstracts of the General Meeting of the American Society for Microbiology 101: 229, 2001