+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sustained-release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy

Sustained-release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy

American Journal of Obstetrics & Gynecology 172(2 Part 1): 562-567

OBJECTIVE: Efficacy and acceptability of continuous combined parenteral hormone replacement consisting of subdermal estradiol delivery and intrauterine progestin delivery was studied. STUDY DESIGN: Thirty-six volunteer postmenopausal women seeking treatment for climacteric symptoms participated in this open, randomized study. The subjects received either one or three subdermal implants with a controlled daily release of estradiol in vitro. Progestin therapy was carried out with a levonorgestrel-releasing intrauterine device. Climacteric symptoms and serum concentrations of estrone, estradiol, follicle-stimulating hormone, and sex hormone-binding globulin were followed up for 1 year. The subjects kept daily records of bleeding. RESULTS: Serum estradiol concentrations with the set of three implants were stable during the follow-up period; the range of mean serum estradiol concentrations was 45 to 57 pg/ml. Four women, all from the group with one implant, discontinued the study after 6 months because of the return of climacteric symptoms. In spite of different daily estradiol doses, the patterns of bleeding were similar in both groups. At the end of the follow-up year 72% of the women had had no bleeding or spotting in the previous 3 months. CONCLUSION: Our results suggest that by combining subdermal and intrauterine steroid delivery systems postmenopausal hormone replacement therapy can be carried out successfully without daily effort and with minimal or no bleeding.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 009498944

Download citation: RISBibTeXText

PMID: 7856686

DOI: 10.1016/0002-9378(95)90573-1

Related references

Percutaneous estradiol gel with an intrauterine levonorgestrel releasing device or natural progesterone in hormone replacement therapy. Maturitas. 26(3): 211-217, 1997

Endometrial morphology during hormone replacement therapy with estradiol gel combined to levonorgestrel-releasing intrauterine device or natural progesterone. Acta Obstetricia Et Gynecologica Scandinavica. 77(7): 758-763,., 1998

Three-year follow-up of the use of a levonorgestrel-releasing intrauterine system in hormone replacement therapy. Acta Obstetricia et Gynecologica Scandinavica 76(2): 145-150, 1997

Intrauterine release of levonorgestrel a new way of adding progestogen in hormone replacement therapy. Obstetrics & Gynecology 79(6): 963-967, 1992

Effect of the levonorgestrel-releasing intrauterine system on the uterine artery pulsatility index in postmenopausal hormone replacement therapy. Ultrasound in Obstetrics and Gynecology 10(5): 350-355, 1998

Sustained-release subdermal estradiol implants: A new alternative in estrogen replacement therapy. American Journal of Obstetrics and Gynecology 169(5): 1248-1254, 1993

Three years' experience with levonorgestrel-releasing intrauterine device and Norplant-2 implants: a randomized comparative study. Advances in Contraception 8(2): 105-114, 1992

In vivo release kinetics of levonorgestrel-releasing intrauterine device. Zhongguo Yiyao Gongye Zazhi 26(11): 494-496, 1995

Insulin sensitivity during postmenopausal hormone replacement with transdermal estradiol and intrauterine levonorgestrel. Acta Obstetricia et Gynecologica Scandinavica 78(6): 540-545, 1999

Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints versus estradiol-releasing vaginal ring with a vaginal progesterone suppository: Clinical and endometrial responses. Maturitas 26(2): 103-111, 1997

Protective effect of intrauterine release of levonorgestrel on pelvic infection: three years' comparative experience of levonorgestrel- and copper-releasing intrauterine devices. Obstetrics and Gynecology 77(2): 261-264, 1991

The effect of levonorgestrel-releasing intrauterine device on menorrhagia in women taking anticoagulant medication after cardiac valve replacement. Contraception 80(2): 152-157, 2009

Two years' experience with two levonorgestrel-releasing intrauterine devices and one copper-releasing intrauterine device: a randomized comparative performance study. Fertility and Sterility 39(2): 187-192, 1983

Use of a levonorgestrel releasing intrauterine device in substitutive estrogenic therapy in menopause. Maturitas 27(Suppl. ): 211, 1997

The role of copper-releasing intrauterine device or levonorgestrel-releasing intrauterine system on uterine bleeding and iron status (prospective study of 8 years). Minerva Ginecologica 54(3): 271-278, 2002