+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Synovial fluid L-lactic acid in acute arthritis of the adult knee joint

Synovial fluid L-lactic acid in acute arthritis of the adult knee joint

Scandinavian Journal of Rheumatology 24(2): 98-101

Determination of synovial fluid (SF) lactic acid has been suggested to be an unspecific indicator of SF leukocytosis, and it is not recommended for differential diagnosis of bacterial arthritis. We analyzed the L-lactic acid content by enzymatic UV-method in 65 SF samples obtained from adult patients with acute knee arthritides. The concentration of L-lactic acid was not high in any SFs with intensive leukocytosis. The mean concentration of L-lactic acid was 13.5 mmol/l (95% confidence intervals 9.4; 17.6 mmol/l) in the synovial-fluid samples from culture-positive arthritis and 5.5 mmol/l (4.9; 6.2 mmol/l) in the synovial-fluid samples from culture-negative arthritis. Determination of SF L-lactic acid is an important part of the diagnostic setup for acute arthritis. Values > 9 mmol/l strongly support occurrence of bacterial arthritis and indicates an immediate onset of the treatment.

(PDF emailed within 0-6 h: $19.90)

Accession: 009502744

Download citation: RISBibTeXText

PMID: 7747151

DOI: 10.3109/03009749509099292

Related references

Synovial-fluid D-lactic acid in bacterial and other acute joint effusions. Scandinavian Journal of Rheumatology 23(4): 203-205, 1994

Cartilage and bone macromolecules in knee joint synovial fluid in rheumatoid arthritis: relation to development of knee or hip joint destruction. Annals of the Rheumatic Diseases 56(2): 91-96, 1997

Knee joint synovial fluid content of aggrecan predicts knee/hip joint destruction in rheumatoid arthritis. Arthritis & Rheumatism 38(9 SUPPL ): S288, 1995

Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint. Arthritis Research & Therapy 12(4): R148-R148, 2011

Synovial fluid leukocytosis in bacterial arthritis vs. reactive arthritis and rheumatoid arthritis in the adult knee. Scandinavian Journal of Rheumatology 21(6): 283-288, 1992

Ultrastructure of the cells of synovial fluid of the knee joint in traumatic arthritis. Laboratornoe Delo 8: 470-473, 1973

Role of cathepsin D of synovial fluid of the knee joint in the pathogenesis of traumatic arthritis. Vestnik Khirurgii Imeni I. I. Grekova 134(6): 103-106, 1985

Levels of hormones in plasma and in synovial fluid of knee joint of patients with rheumatoid arthritis. Casopis Lekaru Ceskych 146(3): 292-296, 2007

Synovial fluid lactic acid in septic arthritis. New Zealand Medical Journal 93(678): 115-117, 1981

The value of synovial fluid analysis in the assessment of knee joint destruction in arthritis in a three year follow up study. Annals of the Rheumatic Diseases 58(9): 559-562, 1999

Synovial fluid acidosis correlates with radiological joint destruction in rheumatoid arthritis knee joints. Journal of Rheumatology 16(4): 468-472, 1989

Synovial fluid lactic acid levels in septic arthritis. Pathology 13(1): 69-71, 1981

Synovial fluid lactic acid in septic and nonseptic arthritis. Arthritis & Rheumatism 26(12): 1499-1505, 1983

Synovial fluid lactic acid. A diagnostic aid in septic arthritis. Arthritis and Rheumatism 21(7): 774-779, 1978

Lactic acid concentration in synovial fluid of patients with rheumatoid joint inflammation. Reumatologia (Warsaw) 35(3): 373, 1997