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Synthesis and antiulcer activity of N-2-(2-hydroxy-2-phenyl)ethyl-N"-(methanesulfonyl)guanidine analogue of ranitidine. Development of a new antiulcer agent T-593



Synthesis and antiulcer activity of N-2-(2-hydroxy-2-phenyl)ethyl-N"-(methanesulfonyl)guanidine analogue of ranitidine. Development of a new antiulcer agent T-593



Yakugaku Zasshi 118(3): 88-104



A series of the aryl-substituted N'-2-(2-hydroxy-2-phenyl)ethyl derivatives of N-methanesulfonyl-N-2-((5-dimethylaminomethyl or 5-methylaminomethyl) furfurylthio)ethylguanidine have been synthesized as potential antisecretory and mucosal protective antiulcer agents. The synthetic routes involves, at the last stage, the reaction of 2-hydroxy-2-phenylethylamines with N-2-(furfurylthio)ethyl-N'-methanesulfonyl-S-methylisothiourea or its O-phenylisourea counterpart.

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Accession: 009503985

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PMID: 9549432



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