Section 10
Chapter 9,508

Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase

Terada, T.; Kitazume, S.; Kitajima, K.; Inoue, S.; Ito, F.; Troy, F.A.; Inoue, Y.

Journal of Biological Chemistry 268(4): 2640-2648


ISSN/ISBN: 0021-9258
PMID: 8381411
Accession: 009507473

The sugar nucleotide, cytidine 5'-(3-deoxy-D-glycero-D-galacto-2-nonulosonic phosphate) (CMP-KDN) is expected to serve as a donor of KDN residues in the synthesis of KDN-containing glycoconjugates. We report here the identification and characterization of CMP-KDN synthetase, a novel enzyme responsible for synthesis of CMP-KDN from KDN and CTP.

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