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Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis

Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis

American Journal of Psychiatry 152(3): 444-446

Objective: The authors measured the ratio of N-acetyl aspartate (a putative neuronal marker) to creatine-phosphocreatine in patients with first-episode psychosis by using proton magnetic resonance spectroscopy (MRS). Method: Temporal lobe 1H MRS was performed bilaterally on 13 patients with first-episode psychosis and 15 comparison subjects. The N-acetyl aspartate/creatine-phosphocreatine and choline/creatine-phosphocreatine ratios were determined. Results: The N-acetyl aspartate/creatine-phosphocreatine ratio of the psychotic patients was significantly lower than that of the comparison subjects. Conclusions: These preliminary data suggest that abnormalities in temporal lobe N-acetyl aspartate concentration are present early in psychotic illness.

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Accession: 009523207

Download citation: RISBibTeXText

PMID: 7864274

DOI: 10.1176/ajp.152.3.444

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