+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The calcium receptor in health and disease

The calcium receptor in health and disease

Experimental Nephrology 6(3): 171-179

The recent cloning of a G-protein-coupled, extracellular calcium [(Ca2+)e]-sensing receptor (CaRG) from the parathyroid, kidney and brain of several species has clarified the molecular mechanisms underlying Ca2+-sensing by parathyroid and other cell types. It has long been suspected that such a receptor existed on parathyroid cells, coupled to intracellular second messengers through guanine nucleotide regulatory (G) protein which is able to recognize and respond to (Ca2+)e. Recently, functional screening of a cDNA library constructed from bovine parathyroid mRNA led to the isolation of a 5.3-kb clone expressing maximal Ca2+-stimulated Cl- currents in oocytes. This 5.3-kb cDNA encodes a protein of 1,085 amino acids with three principal predicted structural domains. The CaRG protein is present in chief parathyroid cells, in C cells of the thyroid, in the cortical thick ascending limb (TAL) and collecting duct of the kidney, and in discrete brain areas. CaRG may play several physiological roles. It is a central element in the control of both parathyroid and calcitonin secretion by (Ca2+)e. Moreover, functional evidence for its participation in the regulation of renal Ca2+ reabsorption in TAL and water reabsorption in the collecting duct has been obtained. Mutations of the CaRG gene are responsible for hereditary and familial parathyroid disorders, and a decrease in CaRG expression has been documented in primary and secondary uremic hyperparathyroidism. The expression of CaRG in several additional organs and tissues allows speculation on the potential involvement in other pathologies.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 009546602

Download citation: RISBibTeXText

PMID: 9639031

Related references

The calcium-sensing receptor: insights into extracellular calcium homeostasis in health and disease. Journal of Endocrinology 154(3): 371-378, 1997

The Calcium-Sensing Receptor in Health and Disease. International Review of Cell and Molecular Biology 327: 321-369, 2016

The many roles of the calcium-sensing receptor in health and disease. Archives of Medical Research 30(6): 436-448, 2000

Calcium-sensing receptor: Role in health and disease. Indian Journal of Endocrinology and Metabolism 16(Suppl 2): S213-S216, 2012

The extracellular calcium-sensing receptor: its role in health and disease. Annual Review of Medicine 49: 15-29, 1998

The role of the extracellular calcium-sensing receptor in health and disease. Experimental and Clinical Endocrinology & Diabetes 114(8): 397-405, 2006

Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovascular Research 77(2): 245-255, 2008

Keeping up with calcium: conference on calcium-binding proteins and calcium function in health and disease. Embo Reports 3(9): 823-827, 2002

The Symposia on Calcium Binding Proteins and Calcium Function in Health and Disease: an historical account, and an appraisal of their role in spreading the calcium message. Cell Calcium 37(4): 279-281, 2005

Does protein kinase a-mediated phosphorylation of the cardiac ryanodine receptor play any role in adrenergic regulation of calcium handling in health and disease?. Circulation Research 106(11): 1672-1674, 2010

"The role of the calcium sensing receptor (CaSR) in health and disease, implications for translational medicine" or the multifaceted CaSR: a Training Network for young scientists. Best Practice and Research. Clinical Endocrinology and Metabolism 27(3): 279-281, 2013

The role of the calcium-sensing receptor in disorders of abnormal calcium handling and cardiovascular disease. Current Opinion in Nephrology and Hypertension 23(5): 494-501, 2014

Role of calcium-sensing receptor gene in calcium and phosphate metabolism in end-stage renal disease. Nephrology Dialysis Transplantation 17(Abstracts Suppl. 1): 197, 2002

The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease. Annual Review of Physiology 74: 271-297, 2012