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The delayed respiratory consequences of inhaled radionuclides in population exposed to nuclear catastrophe

Chuchalin, A.G.; Grobova, O.M.; Cherniaev, A.L.; Tatarsky, A.R.; Hoffshir, D.; Voisin, C.

Stem Cells 13(Suppl): 276-282

1995


ISSN/ISBN: 1066-5099
PMID: 7488957
DOI: 10.1002/stem.5530130734
Accession: 009553876

Cytological analysis of bronchoalveolar lavage (BAL) and x-ray energy dispersive spectrometry of intercellular compounds were evaluated in 19 workers ("liquidators") commissioned to clean and contain the nuclear waste after the Chernobyl catastrophe in comparison with ten control subjects. Results showed a significant increase of neutrophils, small monocyte-like alveolar macrophages (AM) and AM with large black cytoplasmic inclusions. In addition, such mineral elements as Zr, Ce, Pr, Sm, Pa, PU and Cs were detected in AM phagosomes in liquidators. These elements were reported as markers of Chernobyl-type nuclear fuel. It is recognized that BAL gives access to particulate matter present in lung parenchyma. Thus, spectrometric analysis of AM inclusions can provide reliable information about the exposure to inhaled radionuclides seven years after the catastrophe.

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