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The effect of penetration enhancers on the transdermal absorption of metoclopramide

Lu, J.; Du, Y.; Zhao, Y.; Xu, H.

Acta Academiae Medicinae Shanghai 21(3): 205-207

1994


Accession: 009565347

V-C horizontal diffusion cell was used to measure the transfer of metoclopramide across intact abdominal mouse skin in vitro. The effect of penetration enhancers, propylene glycol, oleic acid, and azone-propylene glycol on the permeability of metoclopramide was investigated. the results indicated the feasibility of utilization of penetration enhancers to improve the transdermal absorption of metoclopramide: The permeation coefficients of metoclopramide raised with presence of various kinds of transdermal enhancers.

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