+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The effects of antidepressant drugs on salivary flow and content of sodium and potassium ions in human parotid saliva



The effects of antidepressant drugs on salivary flow and content of sodium and potassium ions in human parotid saliva



Archives of Oral Biology 40(11): 983-989



Stimulated parotid saliva was collected, using the Carlson-Crittenden cup, from normal controls and patients on antidepressant drugs. The saliva from patients using amitriptyline, dothiepin (tricyclics), fluoxetine and paroxetine (selective serotonin re-uptake inhibitors; SSRI) was analysed for flow rate, (Na+) and (K+), and was compared with that from unmedicated, non-depressed volunteers for all variables. The tricyclic antidepressants produced a significant reduction in flow (amitriptyline, p lt 0.01; dothiepin, p lt 0.05), and consequent decrease in (Na+) and increase in (K+). These effects were presumably due to muscarinic receptor blockade. The SSRIs produced no significant change in these variables. A prospective study of dothiepin in non-depressed patients confirmed that it decreases stimulated parotid flow. This finding also suggested that depression itself contributed little to the oral dryness observed in and reported by the depressed patients. The patients' subjective rating of oral dryness related well to a reduction in stimulated flow. This applied to those taking either tricyclics or SSRI, both showing a reduced flow rate relative to control (p lt 0.001 and p lt 0.05, respectively). This amounted to a 58% reduction in flow rate in the tricyclic group. The data suggest that measurement of stimulated parotid salivary flow is a reliable indicator of drug-induced oral dryness.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009569617

Download citation: RISBibTeXText

PMID: 8670028

DOI: 10.1016/0003-9969(95)00079-5


Related references

Investigation on the influence of the various autonomic nervous drugs on the salivary secretion and also on the concentration of sodium and potassium in the human saliva. . On the effects of a certain number of parasympathetic blockades and ganglionic blockades on the salivary secretion and also on the concentration of sodium and potassium in saliva. Bull Tokyo Med And Dental Univ 5(4): 519-537, 1958

Investigation on the influence of the various autonomic nervous drugs on the salivary secretion and also on the concentration of sodium and potassium in the human saliva On the fluctuations of the salivary secretion and also on the concentration of sodium and potassium in saliva following the injection of a sympathetic stimulant, neo-synephrin. Bull Tokyo Med And Dental Univ: 539-552, 1958

Investigations on the various influence of the autonomic nervous drugs on the salivary secretion and also on the concentration of sodium and potassium in the human saliva On the influence of the svmpatholytic and the parasvmpatho-mimetic drugs on the salivary secretion and also on the concentration of sodium and potassium in saliva. Bull Tokyo Med And Dental Univ: 509-517, 1958

Effects of the diuretic furosemide on the flow rate and concentration of sodium potassium and chloride in human parotid saliva. Journal of Dental Research 55(SPEC ISSUE D): D107, 1976

On the effects of the sympathico-and parasympathico-mimetic drugs, pituitary and adrenocortical hormones upon the concentrations of sodium and potassium in the human saliva I On the normal range and the days fluctuation of the sodium and potassium values in the human saliva measured by the flame spectro-photometry. Bull Tokyo Med And Dental Univ: 155-163, 1957

Salivary secretion in pregnancy a longitudinal study of flow rate total protein sodium potassium and calcium concentration in parotid saliva from pregnant women. Acta Odontologica Scandinavica 30(1): 49-66, 1972

On the effects of the sympathico-and para-sympathico-mimetic drugs, pituitary and adrenocortical hormones upon the concentrations of sodium and potassium in the human saliva. II. The effect of the sympathico- and the parasympathico-mimetic drugs on sodium and potassium in the human saliva. Bull Tokyo Med And Dental Univ 4(2): 165-171, 1957

Interrelationships between flow rate, amylase, calcium, sodium, potassium and inorganic phosphate in stimulated human parotid saliva. Archives of Oral Biology 21(11): 645-650, 1976

Changes in the content of sodium and potassium ions in human urine and saliva during "elevations" to the altitude of 5,000 m and 6,000 m in pressure chambers. Biulleten' Eksperimental'noi Biologii i Meditsiny 53: 63-65, 1962

The secretion of parathyroid hormone-related protein in the saliva of sheep and its effects on the salivary clearance of phosphate, calcium, magnesium, potassium and sodium ions. Experimental Physiology 80(4): 589-595, 1995

Effects of aldosterone on renal sodium and potassium excretion as well as sodium and potassium levels in saliva and rumen content in sheep exposed to excess potassium. Monatshefte fur Veterinarmedizin 31(2): 46-51, 1976

Effects of aldosterone on renal sodium and potassium excretion as well as sodium and potassium levels in saliva and rumen content in sheep exposed to potassium supercharge. Monatshefte fur Veterinarmedizin: 31 (2) 46-51, 1976

Effect of sodium restriction on secretion of sodium and potassium in human parotid saliva. Journal of Applied Physiology 9(3): 477-480, 1956

Effect of Sodium Restriction on Secretion of Sodium and Potassium in Human Parotid Saliva. Journal of Applied Physiology 9(3): 477-480, 1956

Effects of parathyroid hormone on total protein calcium magnesium phosphorus sodium and potassium concentrations of normal human parotid saliva. European Journal of Clinical Investigation 7(2): 121-126, 1977