Section 10
Chapter 9,585

The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulation

Caswell, R.; Hagemeier, C.; Chiou, C.J.; Hayward, G.; Kouzarides, T.; Sinclair, J.

Journal of General Virology 74: 2691-2698


ISSN/ISBN: 0022-1317
PMID: 8277274
DOI: 10.1099/0022-1317-74-12-2691
Accession: 009584291

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The 86K immediate early (IE) 2 protein of human cytomegalovirus trans-activates a number of homologous and heterologous promoters, including the cellular promoter for the 70K heat-shock protein (hsp70), and the human immunodeficiency virus long terminal repeat. We have previously shown that IE2 trans-activates these two promoters in a TATA-dependent manner, and that IE2 is able to form a direct contact with TATA-box binding protein (TBP) in vitro.

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