+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

Neurology 50(5): 1346-1350

We assessed exposure to pesticides, farming, well water use, and rural living as risk factors for Parkinson's disease (PD) in a population-based case-control study consisting of men and women > or = 50 years of age who had primary medical care at Henry Ford Health System in metropolitan Detroit. Enrolled PD patients (n = 144) and control subjects (n = 464) were frequency-matched for age, race, and sex. When adjusted for these variables and smoking status, there was a significant association of occupational exposure to herbicides (odds ratio [OR], 4.10; 95% CI, 1.37, 12.24) and insecticides (OR, 3.55; 95% CI, 1.75, 7.18) with PD, but no relation was found with fungicide exposure. Farming as an occupation was significantly associated with PD (OR, 2.79; 95% CI, 1.03, 7.55), but there was no increased risk of the disease with rural or farm residence or well water use. The association of occupational exposure to herbicides or insecticides with PD remained after adjustment for farming. The association of farming with PD was maintained after adjustment for occupational herbicide exposure and was of borderline significance after adjustment for occupational insecticide exposure. These results suggest that PD is associated with occupational exposure to herbicides and insecticides and to farming and that the risk of farming cannot be accounted for by pesticide exposure alone.

(PDF emailed within 0-6 h: $19.90)

Accession: 009617855

Download citation: RISBibTeXText

PMID: 9595985

DOI: 10.1212/wnl.50.5.1346

Related references

Association between Parkinson's Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis. Plos One 11(4): E0151841-E0151841, 2016

Exposure to pesticides or solvents and risk of Parkinson disease. Neurology 80(22): 2035-2041, 2013

Parkinson's disease risk from ambient exposure to pesticides. European Journal of Epidemiology 26(7): 547-555, 2011

Pesticides: double exposure heightens Parkinson disease risk. Environmental Health Perspectives 117(7): A295-A295, 2009

Use of a VA pharmacy database to screen for areas at high risk for disease: Parkinson's disease and exposure to pesticides. Journal of Geriatric Psychiatry and Neurology 17(1): 36-38, 2004

Exposure to well water and pesticides in Parkinson's disease: a case-control study in the Madrid area. Movement Disorders 7(2): 149-152, 1992

Herbicide pesticide exposure independent of rural living as a risk factor for parkinsons disease. Neurology 42(4 SUPPL 3): 174, 1992

A national registry to determine the distribution and prevalence of Parkinson's disease in Thailand: implications of urbanization and pesticides as risk factors for Parkinson's disease. Neuroepidemiology 37(3-4): 222-230, 2012

Access to farming pesticides and risk for suicide in Chinese rural young people. Psychiatry Research 179(2): 217-221, 2010

Professional exposure to pesticides and Parkinson disease. Annals of Neurology 66(4): 494-504, 2009

A meta-analysis of Parkinson's disease and exposure to pesticides. Neurotoxicology 21(4): 435-440, 2000

Exposure to home pesticides linked to Parkinson disease. JAMA 283(23): 3055-3056, 2000

Alzheimer's disease with secondary Parkinson's syndrome. Case report of a patient with dementia and Parkinson's syndrome after long-term occupational exposure to insecticides, herbicides, and pesticides. Der Nervenarzt 75(11): 1107-1111, 2004

Rural or urban living and Parkinson's disease. Arquivos de Neuro-Psiquiatria 54(1): 37-41, 1996

Scleroderma-like lesions and Parkinson's disease: possible links with exposure to pesticides. European Journal of Dermatology 17(3): 256-257, 2007