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The role of estrogen support during the luteal phase of in vitro fertilization-embryo transplant cycles: a comparative study between progesterone alone and estrogen and progesterone support



The role of estrogen support during the luteal phase of in vitro fertilization-embryo transplant cycles: a comparative study between progesterone alone and estrogen and progesterone support



Fertility and Sterility 62(1): 121-125



Objective: To evaluate the possible role for estrogen supplementation to the P luteal phase support of GnRH agonists (GnRH-a)- and hMG-induced IVF-ET cycles. Setting: In vitro fertilization unit in a tertiary care university hospital. Design: A prospectively randomized study. Patients: One hundred consecutive patients undergoing ET after IVF were assigned into one of two luteal supplementation regimens. Interventions: In all patients enrolled in the study, ovulation was induced using the midluteal regimen for pituitary down regulation with GnRH-a followed by follicular stimulation with hMG. The first group received IM P 50 mg/d, as luteal phase Support, Starting the day of ET. The second group received the same dosage of P, combined with oral E-2 valerate, 2 mg/d. Serum levels of P and E-2 were monitored every 4 days for 16 days after ET. Main Outcome Measures: Pregnancy rates (PRs) and live birth rates per ET. Results: No significant difference in E. or P levels throughout the cycle was observed between groups. Similar PRs per ET and the live birth rates were also observed between group A and B (28% versus 26.5% and 78.6% versus 76.1%, respectively). Conclusion: No advantage was found in the addition of E, valerate to P luteal phase support of GnRH-a- and hMG-induced IVF-ET cycles.

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Accession: 009620051

Download citation: RISBibTeXText

PMID: 8005275

DOI: 10.1016/s0015-0282(16)56826-5



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