Section 10
Chapter 9,634

The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization

Vanetti, M.; Vogt, G.; Höllt, V.

Febs Letters 331(3): 260-266


ISSN/ISBN: 0014-5793
PMID: 8104154
Accession: 009633237

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The somatostatin receptor 2 (mSSTR2) is alternatively spliced into two isoforms (mSSTR2A and mSSTR2B) which differ at the C-terminus. Both receptors bind somatostatin peptides with a similar high affinity when stably expressed in CHO-K1 cells. However, the spliced form (mSSTR2B) mediates a more efficient inhibition of adenylate cyctase and is much more resistant to agonist-induced reduction of binding than the longer form (mSSTR2A).

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