+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Three-year follow-up of the Fluorouracil Filtering Surgery Study



Three-year follow-up of the Fluorouracil Filtering Surgery Study



American Journal of Ophthalmology 115(1): 82-92



Patients who participated in the Fluorouracil Filtering Surgery Study, a clinical trial in which patients were randomly assigned to treatment to determine the efficacy and safety of subconjunctivally injected 5-fluorouracil after filtering surgery in eyes with poor prognoses, were followed up for three years. Treatments in 49 of the 100 eyes in the 5-fluorouracil group and 73 of the 99 eyes (74%) in the standard treatment group were classified as failures, defined by reoperation for control of intraocular pressure or intraocular pressure greater than 21 mm Hg during the first three years postoperatively (P < .001, chi-square). Late-onset leakage of aqueous through the filtering bleb occurred more frequently in the 5-fluorouracil group (seven of 105 eyes, 7%) than in the standard treatment group (none of 108 eyes, 0%) (P = .006, Fisher's exact test). We recommend the use of 5-fluorouracil after trabeculectomy in eyes after previous cataract extraction or unsuccessful filtering surgery. The increased risk of late-onset conjunctival filtering bleb leaks associated with 5-fluorouracil cautions against its routine use in patients with good prognoses.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009646213

Download citation: RISBibTeXText

PMID: 8420383

DOI: 10.1016/s0002-9394(14)73529-9


Related references

Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group. American Journal of Ophthalmology 108(6): 625-635, 1989

Fluorouracil Filtering Surgery Study One-Year Follow-up. American Journal of Ophthalmology 186: Xxxiii-Xxxlii, 2018

Five-year follow-up of the fluorouracil filtering surgery study. American Journal Of Ophthalmology. 121(4): 349-366, 1996

Fluorouracil filtering surgery study one-year follow-up. American Journal of Ophthalmology 109(5): 613-616, 1990

5-Fluorouracil and glaucoma filtering surgery. III. Intermediate follow-up of a pilot study. Ophthalmology 93(12): 1537-1546, 1986

5-Fluorouracil filtering surgery and neovascular glaucoma. Long-term follow-up of the original pilot study. Ophthalmology 102(6): 887-92; Discussion 892-3, 1995

Risk factors for suprachoroidal hemorrhage after filtering surgery. The Fluorouracil Filtering Surgery Study Group. American Journal of Ophthalmology 113(5): 501-507, 1992

Long-term follow-up of primary filtering surgery with mitomycin or 5-fluorouracil. IOVS 40(4): S268, March 15, 1999

Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up. Ophthalmology 102(9): 1263-1269, 1995

Mitomycin-C versus 5-fluorouracil in high-risk glaucoma filtering surgery-extended follow-up. Investigative Ophthalmology & Visual Science 35(4): 1428, 1994

Postoperative 5-fluorouracil versus intraoperative mitomycin C in high-risk glaucoma filtering surgery: extended follow up. Clinical and Experimental Ophthalmology 31(3): 199-205, 2003

A comparative study of homoharringtonine with 5-fluorouracil in filtering surgery. Yan Ke Xue Bao 10(2): 108-112, 1994

5-fluorouracil and glaucoma filtering surgery. II. A pilot study. Ophthalmology 91(4): 384-394, 1984

Phase III trial of adjuvant 5-fluorouracil and adriamycin versus 5-fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (poly A:U) for locally advanced gastric cancer after curative surgery: final results of 15-year follow-up. Annals of Oncology 19(3): 520-526, 2007

5-Fluorouracil and filtering surgery. Australian and New Zealand Journal of Ophthalmology 19(3): 173, 1991