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Transdermal absorption of nifedipine from microemulsions of lipophilic skin penetration enhancers


Transdermal absorption of nifedipine from microemulsions of lipophilic skin penetration enhancers



International Journal of Pharmaceutics (Amsterdam) 111(3): 235-240



DOI: 10.1016/0378-5173(94)90346-8

Oil/water microemulsions of six lipophilic skin penetration enhancers (oil of ylang ylang, lavender oil, cinnamon oil, cineole, menthone and menthol) containing ethanol as emulsifying agent were prepared. These systems were used as vehicles for the percutaneous absorption of nifedipine. The effect of microemulsions containing 50 and 25% ethanol on the percutaneous absorption of nifedipine were compared with formulations consisting of solutions of penetration enhancers in 100% ethanol. Microemulsions containing 50% ethanol were found to be superior vehicles for the percutaneous absorption of nifedipine. A probable mechanism by which microemulsions enhance the percutaneous absorption of drugs effectively is explained.

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Accession: 009662579

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