EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Ultra-high resolution SPECT system using four pinhole collimators for small animal studies



Ultra-high resolution SPECT system using four pinhole collimators for small animal studies



Journal of Nuclear Medicine 36(12): 2282-2287



We describe a newly developed ultra-high resolution SPECT system using four pinhole collimators for small animal studies. Methods: The system utilizes a clinical four-head SPECT scanner with specially designed pinhole collimators. Four types of pinholes with different configurations were designed with different effective aperture sizes (1.0, 2.0 and 4.0 mm) and rotating radii (40 mm and 50 mm). The distance from the axis of rotation to the scintillator was fixed to 180 mm. A filtered backprojection algorithm was used to reconstruct SPECT images after fan-beam-to-parallel-beam data conversion. Results: The system provided a reconstructed spatial resolution of 1.65 mm (FWHM) and sensitivity of 4.3 kcps/mu-Ci/ml with the best type of pinholes, respectively. The 99mTc-HMPAO SPECT image in rat studies clearly visualized small brain structures, and the left ventricular myocardium and cardiac cavity were clearly separated with 99mTc-MIBI. Dynamic SPECT imaging of rat brain with (123I)iomazenil was also feasible. Conclusion: This ultra-high resolution SPECT system can be used to measure the regional distribution of radiolabeled tracers in small animals in vivo and may play a significant role in the development of new radiopharmaceuticals and in studies of various disease models using living animals.

(PDF emailed within 1 workday: $29.90)

Accession: 009690006

Download citation: RISBibTeXText

PMID: 8523120



Related references

Pinhole SPECT: ultra-high resolution imaging for small animal studies. Journal of Nuclear Medicine 36(12): 2287-2289, 1995

Application of an ultra high-resolution pinhole SPECT system based on a conventional camera for small animal imaging. Journal of Nuclear Medicine 42(5 Supplement): 54P-55P, 2001

Ultra-high resolution SPECT images with uranium pinhole collimators. Journal of Nuclear Medicine 40(5 SUPPL ): 34P, 1999

High resolution 4-head pinhole SPECT system for small animal studies. Journal of Nuclear Medicine 35(5 SUPPL ): 196P, 1994

Development of a high-resolution pinhole SPECT system using dual-head gamma camera for small animal studies. Kaku Igaku. Japanese Journal of Nuclear Medicine 35(9): 901-907, 1999

Pinhole collimation for ultra-high resolution, small-field-of-view SPECT studies. Journal of Nuclear Medicine 34(5 SUPPL ): 10P, 1993

Design of rotating multi-pinhole SPECT system for high resolution small animal imaging. Journal of Nuclear Medicine 39(5 SUPPL ): 174P, 1998

A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging. Brazilian Journal of Medical and Biological Research 43(12): 1160-1166, 2011

Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. Physics in Medicine and Biology 39(3): 425-437, 1994

Estimation of geometrical parameters in ultra-high-resolution pinhole SPECT system. Journal of Nuclear Medicine 44(5 Supplement): 8P, 2003

High resolution pinhole SPECT for small animal imaging. Journal of Nuclear Medicine 34(5 SUPPL ): 9P, 1993

Evaluation of high-resolution pinhole SPECT using a small rotating animal. Journal of Nuclear Medicine 42(12): 1863-1869, 2001

Evaluation of system parameters employed to develop an ultra high resolution SPECT system for small animal imaging. Journal of Nuclear Medicine 43(5 Supplement): 225P, 2002

System calibration and statistical image reconstruction for ultra-high resolution stationary pinhole SPECT. IEEE Transactions on Medical Imaging 27(7): 960-971, 2008

Development of ultra high resolution pinhole SPECT. Journal of Nuclear Medicine 38(5 SUPPL ): 217P, 1997