+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Vaccination of mice against canine distemper virus-induced encephalitis with vaccinia virus recombinants encoding measles or canine distemper virus antigens



Vaccination of mice against canine distemper virus-induced encephalitis with vaccinia virus recombinants encoding measles or canine distemper virus antigens



Vaccine 11(4): 438-444



Measles and canine distemper are caused by serologically related viruses. Although dogs immunized with measles virus (MV) do not elicit canine distemper virus (CDV) neutralizing antibodies, they are protected against the fatal disease. To investigate the potential role of the MV antigens in protection against CDV, we have immunized mice with vaccinia virus (VV) recombinants expressing the MV haemagglutinin (HA), fusion (F), nucleoprotein (NP) and matrix (M) antigens and challenged them with CDV. A partial protection was observed with the VV recombinants expressing the F, NP and M antigens, but not the HA. In contrast, immunization with a VV recombinant expressing the CDV F protein completely protected mice from CDV.

(PDF emailed within 0-6 h: $19.90)

Accession: 009711908

Download citation: RISBibTeXText

PMID: 8470428

DOI: 10.1016/0264-410x(93)90285-6


Related references

Vaccinia virus recombinants expressing either the measles virus fusion or hemagglutinin glycoprotein protect dogs against canine distemper virus challenge. Journal of Virology 65(8): 4263-4274, 1991

Resistance against canine distemper induced by measles virus. I. Measles vaccination in the presence of distemper antibodies. Veterinary Record 83(22): 554-559, 1968

Protection of dogs against canine distemper by vaccination with a canarypox virus recombinant expressing canine distemper virus fusion and hemagglutinin glycoproteins. American Journal of Veterinary Research 58(8): 833-836, 1997

Measles virus and inactivated canine distemper virus induce incomplete immunity to canine distemper. Archives of Virology 82(1): 73-82, 1984

Immunological relationship between measles and canine distemper viruses. I. Inoculation of distemper virus into puppies previously inoculated with measles virus.. Voprosy Virusologii. 5: 577-582, 1960

The Onderstepoort Canine distemper virus strain and measles vaccine protect Nigerian local dogs against local isolates of Canine distemper virus. Nigerian Veterinary Journal 23(2): 51-55, 2002

A study of the immunological relation between measles and canine distemper viruses. I. Infection of puppies with canine distemper virus following experimental measles. Voprosy Virusologii 6: 577-582, 1960

Immunological studies in demyelinating encephalitis associated with vaccinia virus and canine distemper virus infection. Progress in Brain Research 59: 275-279, 1983

Measles virus antigens induce both type-specific and canine distemper virus cross-reactive cytotoxic T lymphocytes in mice: localization of a common Ld-restricted nucleoprotein epitope. Journal of General Virology 74: 2357-2363, 1993

Studies of an established canine kidney cell line canine distemper virus infectious canine hepatic virus canine herpes virus rabies virus. Cornell Veterinarian 58(4): 593-613, 1968

The humoral immune response to recombinant nucleocapsid antigen of canine distemper virus in dogs vaccinated with attenuated distemper virus or DNA encoding the nucleocapsid of wild-type virus. Journal of Veterinary Medicine Series A 48(5): 295-302, 2001

Clinical distemper following initial vaccination in dogs receiving chronic doses of methotrexate abstract virus canine distemper human measles immuno suppressive therapy. Federation Proceedings: 609, 1969

Serologic response to canine distemper viral antigens in gnotobiotic dogs infected with canine distemper virus. Journal of Infectious Diseases 132(4): 384-392, 1975

Canine distemper immunization. Persistence of measles antibodies in dogs vaccinated with measles virus and the effect of passively-transferred measles antibodies on vaccination of puppies with measles virus. Veterinary Medicine, Small Animal Clinician 62(11): 1065-1069, 1967

Antiserum raised in pigs against canine distemper virus and its utility in diagnostic procedures for morbillivirus infections (canine distemper, phocine distemper, rinderpest). Zentralblatt für Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 37(5): 353-362, 1990