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Variability of the pharmacokinetic parameters of amikacin in geriatric patients in an intensive care unit

Variability of the pharmacokinetic parameters of amikacin in geriatric patients in an intensive care unit

Ciencia Pharmaceutica 2(4): 287-291

The infections caused by gram-negative germs are an important cause of morbidity and mortality in severely ill patients admitted in an intensive care unit, specially in geriatric patients. In the present work, the inter and intra-individual variability of the amikacin pharmacokinetic parameters are studied in a population of severely ill elderly patients, being compared with the obtained ones in a control group of non-elderly adults patients. The results pointed out a greater variability, both inter and intra-individual, of the amikacin plasma clearance (Clp) in the geriatric age. The intra-individual variability of the apparent volume of distribution is also greater in the geriatric patients than in the adults patients, showing the former a lesser interindividual variability. The results related with the inter-individual variability of the amikacin pharmacokinetic parameters in the population of nongeriatric patients are similar with the reported and recommended in the literature for its use in the bayesian method for parameters estimation. Oppositely, the group of elderly patients showed a clearly greater coefficient of variation of the amikacin Clp than routinely used in pharmacokinetics.

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Accession: 009715546

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