Virologic and serologic characteristics of a natural chimpanzee lentivirus infection

Peeters, M.; Janssens, W.; Vanden Haesevelde, M.; Fransen, K.; Willems, B.; Heyndrickx, L.; Kestens, L.; Piot, P.; Van Der Groen, G.; Heeney, J.

Virology 211(1): 312-315

1995


ISSN/ISBN: 0042-6822
PMID: 7645227
DOI: 10.1006/viro.1995.1407
Accession: 009725060

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Abstract
This study set out to characterize the unique features of natural lentivirus infection in chimpanzees over time. The virologic and serologic characteristics of this infection were followed longitudinally in a naturally infected chimpanzee together with a small cohort of experimentally HIV-1-infected chimpanzees. The subsequent isolates from the naturally infected chimpanzee were all non-syncytium forming (NSI) versus syncytium forming in the experimentally infected animals. In contrast to HIV-1-infected chimpanzees virus load was higher and plasma viremia occurred but in a cyclic pattern. Serologic followup suggested the development of neutralizing antibodies with subsequent escape of new isolates. Interestingly, the sequence of the principal neutralizing (V3 loop) domain (of HIV-1) remained constant over time. Antibodies to peptides from the V3 loop were type specific. The occurrence of persistent, fluctuating plasma viremia and NSI-type virus variants of this natural lentivirus infection are unique characteristics not previously reported in experimentally infected chimpanzees.

Virologic and serologic characteristics of a natural chimpanzee lentivirus infection