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p53 overexpression in small hepatocellular carcinomas containing two different histologic grades



p53 overexpression in small hepatocellular carcinomas containing two different histologic grades



International Journal of Oncology 12(2): 455-459



There is evidence to suggest that a focus of less-differentiated hepatocellular carcinoma (HCC) may arise within a pre-existing well-differentiated HCC, eventually replacing it. In the present study, the p53 tumor suppressor gene was analyzed by immunohistochemistry in 31 hepato-cellular carcinomas (HCCs) containing two or more regions in the same nodule with different histologic grades. p53 was overexpressed in the nucleus in 13 of 31 HCCs (42%), in seven of which p53 overexpression was seen only in the less-differentiated area of the tumor. This suggests that overexpression of presumed mutant p53 may have contributed to dedifferentiation during the development of HCC.

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Accession: 009743594

Download citation: RISBibTeXText

PMID: 9458375

DOI: 10.3892/ijo.12.2.455


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