Section 10
Chapter 9,754

A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q

Hand, C.K.; Khoris, J.; Salachas, F.

American Journal of Human Genetics 70(1): 1-6


ISSN/ISBN: 0002-9297
DOI: 10.1086/337945
Accession: 009753181

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A genome scan and linkage analysis was conducted using a large European kindred without superoxide dismutase 1 mutation and with classic autosomal dominant adult-onset amyotrophic lateral sclerosis (ALS). A novel locus was identified. At recombination fraction 0.0, the maximum LOD score is 4.5 for polymorphism D18S39. A 7.5 cM, 8 Mb region of chromosome 18q21 that was flanked by markers D18S846 and D18S1109 was identified as a novel familial ALS locus.

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