A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q
Hand, C.K.; Khoris, J.; Salachas, F.
American Journal of Human Genetics 70(1): 1-6
2002
ISSN/ISBN: 0002-9297 DOI: 10.1086/337945
Accession: 009753181
A genome scan and linkage analysis was conducted using a large European kindred without superoxide dismutase 1 mutation and with classic autosomal dominant adult-onset amyotrophic lateral sclerosis (ALS). A novel locus was identified. At recombination fraction 0.0, the maximum LOD score is 4.5 for polymorphism D18S39. A 7.5 cM, 8 Mb region of chromosome 18q21 that was flanked by markers D18S846 and D18S1109 was identified as a novel familial ALS locus.
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Hand, C.K.; Khoris, J.; Salachas, F.ço.; Gros-Louis, F.ço.; Lopes, A.A.él.S.õe.; Mayeux-Portas, V.; Brewer, C.G.; Brown, R.H.; Meininger, V.; Camu, W.; Rouleau, G.A. 2002: A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q American Journal of Human Genetics 70(1): 251-256Goto, J.; Figlewicz, D.A.; Khodr, N.; Krizus, A.; Mcinnis, M.G.; Warren, A.C.; Haines, J.L.; BrownR.H.Jr.; Antonarakis, S.E.; Rouleau, G.A. 1992: Genetic mapping of the familial amyotrophic lateral sclerosis locus on chromosome 21 American Journal of Human Genetics 51(4 Suppl): A189
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Sapp, P.C.; Hosler, B.A.; Oneill, G.; Bejaoui, K.; Chin, W.; Mckenna Yasek, D.; Francis, J.W.; Horvitz, H.R.; Brown, R.H.Jr 1998: YAC contig map of the recessive familial amyotrophic lateral sclerosis locus on human chromosome 2q33 Society for Neuroscience Abstracts 24(1-2): 488
Vance, C.; Al-Chalabi, A.; Ruddy, D.; Smith, B.N.; Hu, X.; Sreedharan, J.; Siddique, T.; Schelhaas, H.Jurgen.; Kusters, B.; Troost, D.; Baas, F.; de Jong, V.; Shaw, C.E. 2006: Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3 Brain: a Journal of Neurology 129(Pt 4): 868-876
Hosler, B.A.; Sapp, P.C.; Berger, R.; O'Neill, G.; Bejaoui, K.; Hamida, M.B.; Hentati, F.; Chin, W.; McKenna-Yasek, D.; Haines, J.L.; Patterson, D.; Horvitz, H.R.; Brown, R.H.; Day, C.B. 1998: Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33 Neurogenetics 2(1): 34-42
Siddique, T.; Figlewicz, D.A.; Pericak-Vance, M.A.; Haines, J.L.; Rouleau, G.; Jeffers, A.J.; Sapp, P.; Hung, W.Y.; Bebout, J.; McKenna-Yasek, D. 1991: Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity New England Journal of Medicine 324(20): 1381-1384
Abalkhail, H.; Mitchell, J.; Habgood, J.; Orrell, R.; de Belleroche, J. 2003: A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2 American Journal of Human Genetics 73(2): 383-389
King, A.W.; Orrell, R.W.; Lane, R.; de Belleroche, J.S. 1994: More than one locus for familial amyotrophic lateral sclerosis: absence of linkage to the SMA locus Biochemical Society Transactions 22(2): 149s
Chance, P.F.; Ding, Y.; Ryan, S.; George, R.; Scavina, M.; Rabin, B.; Griffin, J.; Cornblath, D.R. 1996: A new locus for juvenile amyotrophic lateral sclerosis on chromosome 9 American Journal of Human Genetics 59(4 Suppl): A89
Siddique T.; Pericak Vance M.A.; Roos R.P.; Watkins P.; Hung W Y.; Brooks B.R.; Noore F.; Tandan R.; Nicholson G.; Et Al 1990: Chromosome 21 markers in familial amyotrophic lateral sclerosis Neurology 40(4 Suppl 1): 315
Maekawa, S.; Leigh, P.N.; King, A.; Jones, E.; Steele, J.C.; Bodi, I.; Shaw, C.E.; Hortobagyi, T.; Al-Sarraj, S. 2009: TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations Neuropathology: Official Journal of the Japanese Society of Neuropathology 29(6): 672-683
Byrne, S.; Heverin, M.; Elamin, M.; Bede, P.; Lynch, C.; Kenna, K.; MacLaughlin, R.; Walsh, C.; Al Chalabi, A.; Hardiman, O. 2013: Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: a population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis Annals of Neurology 74(5): 699-708
Hong, S.; Brooks, B.R.; Hung, W.Y.; Siddique, N.A.; Rimmler, J.; Fan, C.; Kaplan, J.P.; Deng, H.X.; Reyes, R.K.; Brown, R.H.Jr.; Pericak Vance, M.A.; Siddique, T. 1998: X-linked dominant locus for late-onset familial amyotrophic lateral sclerosis Society for Neuroscience Abstracts 24(1-2): 478
Tan, Y.D. 1983: Presence of a large y chromosome in familial amyotrophic lateral sclerosis Zhonghua Shen Jing Jing Shen Ke Za Zhi 16(4): 201-205
Kwiatkowski, T.J.; Bosco, D.A.; Leclerc, A.L.; Tamrazian, E.; Vanderburg, C.R.; Russ, C.; Davis, A.; Gilchrist, J.; Kasarskis, E.J.; Munsat, T.; Valdmanis, P.; Rouleau, G.A.; Hosler, B.A.; Cortelli, P.; de Jong, P.J.; Yoshinaga, Y.; Haines, J.L.; Pericak-Vance, M.A.; Yan, J.; Ticozzi, N.; Siddique, T.; McKenna-Yasek, D.; Sapp, P.C.; Horvitz, H.R.; Landers, J.E.; Brown, R.H. 2009: Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis Science 323(5918): 1205-1208
Siddigue T.; Roos R.P.; Hung W Y.; Jeffers A.J.; Bebout J.; Hu P.; Deng G.; Pericak Vance M.A. 1991: Linkage of familial amyotrophic lateral sclerosis fals to chromosome 21 American Journal of Human Genetics 49(4 Suppl): 17
Hentati, A.; Nijhawan, D.; Karim, O.; Pericak Vance, M.A.; Hung, W.Y.; Hamida, M.B.; Hentati, F.; Siddique, T. 1997: Clinical and genetic locus heterogeneity in autosomal recessive familial amyotrophic lateral sclerosis Neurology 48(3 Suppl 2): A315
Siddique T.; Antonarakis S.; Hu P.; Roos R.P.; Cortelli P.; Hentati A.; Bebout J.; Hung W Y.; Deng G.; Et Al 1992: Mapping a gene for familial amyotrophic lateral sclerosis fals on chromosome 21 Neurology 42(4 Suppl 3): 201
Hentati, A.; Bejaoui, K.; Pericak-Vance, M.A.; Hentati, F.; Speer, M.C.; Hung, W.Y.; Figlewicz, D.A.; Haines, J.; Rimmler, J.; Ben Hamida, C. 1994: Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35 Nature Genetics 7(3): 425-428