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Anti-atherosclerotic properties of nifedipine. Benefit of early intervention to prevent cardiovascular complications

Cardiology 88 Suppl 3: 52-55

Anti-atherosclerotic properties of nifedipine. Benefit of early intervention to prevent cardiovascular complications

Early stages of the atherosclerotic plaque are considered to be responsible for about 2/3 of all acute coronary syndromes. Therefore, suppression of this initial stage of plaque formation constitutes a major target to reduce the incidence of the disease itself as well as its complications. Ca antagonists, like Nifedipine, interfere with Ca++ ions crucially involved in atherogenesis. Consequently, interval angiographic trials with Nifedipine in patients afflicted with coronary artery disease assessed a significant reduction of coronary lesions. Clinical outcome trials will establish the prognostic importance of the anti-atherosclerotic properties of Nifedipine.

Accession: 009770103

PMID: 9397295

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