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Antiallergic component of pig bile

Animal Science & Technology 63(10): 1066-1074

Antiallergic component of pig bile

An antiallergic component was separated from lyophilized pig bile ((PB)) and characterized biochemically. Fr-1-D-1, an active fraction of (PB), was obtained by using an assay system for delayed-type hypersensitivity (DTH) in mice. Fr-1-D-1 showed inhibitory effect only on DTH but not on any inflammatory nor immediate-type allergic reactions examined. Fr-1-D-1 was composed mainly of protein, and showed three major bands ranging from 30 kDa to 90 kDa in SDS-PAGE analysis. The inhibitory activity of Fr-1-D-1 in DTH was inactivated with trypsin digestion or by heating for 3 minutes at 100 degree C, but not with glycosidase digestion nor by heating for 30 minutes at 60 degree C. These results suggest that the antiallergic component of (PB) consists of proteins with DTH-specific inhibitory action.

Accession: 009770198

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