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Antiarrhythmic activity of oximethers

Acta Physiologica Hungarica 83(3): 223-226

Antiarrhythmic activity of oximethers

More than sixty 2-substituted-cycloalkanone-oxim-/2-hydroxy-3-dialkylamino/- propylethers were investigated on aconitine induced ventricular arrhythmia model in rats. According to the structure-activity relationships cyclohexanes containing diisopropylamine in the basic group were the most effective derivatives. Based on the highest per os activity and lowest toxicity EGIS-3966 (ED50 values 1.21 mg/kg iv. and 27.3 mg/kg per os) was selected for further development.

Accession: 009770217

PMID: 8852647

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