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Antibacterial agents based on the cyclic D, L-a-peptide architecture


Nature 412(6845): 2-5
Antibacterial agents based on the cyclic D, L-a-peptide architecture
A new class of antibacterial agents were proven to be effective against a lethal pathogen. New therapeutic agents are required to combat the rapid emergence of drug-resistant bacteria. An assessment of the effectiveness of 6-to-8-residue cyclic D, L-a-peptides against both gram-positive and gram-negative bacteria, including the lethal methicillin-resistant Staphylococcus aureus, demonstrated that this class of cyclic peptides, which possess unique structural features not found in nature, has a high efficacy as antibacterial agents. Thus, the low molecular weight D, L-a-peptides hold considerable potential for use in combating a variety of existing and emerging infectious diseases.

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Accession: 009770247



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