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Antibiotic resistance patterns in Pseudomonas aeruginosa: An 8-year surveillance study in a French hospital



Antibiotic resistance patterns in Pseudomonas aeruginosa: An 8-year surveillance study in a French hospital



International Journal of Antimicrobial Agents 9(2): 107-112



The susceptibility to ticarcillin, piperacillin, ceftazidime, aztreonam, tobramycin, amikacin, ciprofloxacin and fosfomycin of 3876 strains of Pseudomonas aeruginosa isolated during the period 1989-1996 in a French hospital was investigated. The most frequently active agents were amikacin and ceftazidime to which 13.3% and 16.1% of the isolates were resistant. Analysis of beta-lactam susceptibility patterns suggested that cephalosporinase derepression and intrinsic resistance were the predominant underlying mechanisms. There was a trend towards a decline in susceptibility to beta-lactams, aminoglycosides and ciprofloxacin over time. Multiresistance was frequent, mainly in O11 and O12 isolates.

Accession: 009770280

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DOI: 10.1016/s0924-8579(97)00033-2

Download PDF Full Text: Antibiotic resistance patterns in Pseudomonas aeruginosa: An 8-year surveillance study in a French hospital



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