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Antigen presentation and T cell stimulation by dendritic cells






Annual Review of Immunology 20: 621-667

Antigen presentation and T cell stimulation by dendritic cells

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lymphocytes, thus initiating antigen-specific immune responses, or immunological tolerance. Antigen presentation in dendritic cells is finely regulated: antigen uptake, intracellular transport and degradation, and the traffic of MHC molecules are different in dendritic cells as compared to other antigen-presenting cells. These specializations account for dendritic cells' unique role in the initiation of immune responses and the induction of tolerance. Reprinted by permission of the publisher.

Accession: 009770497

PMID: 11861614

DOI: 10.1146/annurev.immunol.20.100301.064828

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