EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Antigen presentation and T cell stimulation by dendritic cells






Annual Review of Immunology 20: 621-667

Antigen presentation and T cell stimulation by dendritic cells

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lymphocytes, thus initiating antigen-specific immune responses, or immunological tolerance. Antigen presentation in dendritic cells is finely regulated: antigen uptake, intracellular transport and degradation, and the traffic of MHC molecules are different in dendritic cells as compared to other antigen-presenting cells. These specializations account for dendritic cells' unique role in the initiation of immune responses and the induction of tolerance. Reprinted by permission of the publisher.

Accession: 009770497

PMID: 11861614

DOI: 10.1146/annurev.immunol.20.100301.064828

Download PDF Full Text: Antigen presentation and T cell stimulation by dendritic cells



Related references

Nakamura, S.; Matsumoto, T.; Jinno, Y.; Sawa, Y.; Hara, J.; Oshitani, N.; Otani, H.; Nagura, H.; Nishiguchi, Y.; Hirakawa, K.; Arakawa, T., 2001: Granuloma consisting cells masquerading mature dendritic cells induce antigen presentation and T cell stimulation in Crohns disease. Gastroenterology 120(5 Supplement 1): A 523, April

Okada, N.; Saito, T.; Mori, K.; Masunaga, Y.; Fujii, Y.; Fujita, J.; Fujimoto, K.; Nakanishi, T.; Tanaka, K.; Nakagawa, S.; Mayumi, T.; Fujita, T.; Yamamoto, A., 2001: Effects of lipofectin-antigen complexes on major histocompatibility complex class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation. We previously reported that exogenous antigens complexed with the cationic liposome lipofectin (LF) were efficiently presented via major histocompatibility complex (MHC) class I molecules on pulsed dendritic cells (DCs) in vitro. In the present st...

Okada, N.; Saito, T.; Mori, K.; Masunaga, Y.; Fujii, Y.; Fujita, J.; Fujimoto, K.; Nakanishi, T.; Tanaka, K.; Nakagawa, S.; Mayumi, T.; Fujita, T.; Yamamoto, A., 2001: Effects of lipofectin-antigen complexes on major histocompatibility complex class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation. We previously reported that exogenous antigens complexed with the cationic liposome lipofectin (LF) were efficiently presented via major histocompatibility complex (MHC) class I molecules on pulsed dendritic cells (DCs) in vitro. In the present st...

Crespo, Mía.I.; Zacca, Eía.R.; Núñez, Nás.G.; Ranocchia, R.P.; Maccioni, M.; Maletto, B.A.; Pistoresi-Palencia, Mía.C.; Morón, G., 2013: TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8α+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface. ssRNA can interact with dendritic cells (DCs) through binding to TLR7, inducing secretion of proinflammatory cytokines and type I IFN. Triggering TLR7 enhances cross-priming of CD8(+) T cells, which requires cross-presentation of exogenous Ag to D...

Wiegand, J.; Cui, Y., 2003: Enhancement of dendritic cell vaccine by improving in vivo antigen presentation through lentiviral vector modified murine bone marrow cells and GM-CSF stimulation. Proceedings of the American Association for Cancer Research Annual Meeting 44: 355-356, July

Mitchell, D.A.; Nair, S.K.; Gilboa, E., 1998: Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. Presentation of MHC class I antigens by professional antigen-presenting cells (APC) is an important pathway in priming cytotoxic T lymphocyte responses in vivo. This study sought to identify the nature of the professional APC responsible for indir...

Mitchell, D.A.; Nair, S.K.; Gilboa, E., 1998: Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. Presentation of MHC class I antigens by professional antigen-presenting cells (APC) is an important pathway in priming cytotoxic T lymphocyte responses in vivo. This study sought to identify the nature of the professional APC responsible for indir...

Zhu, F.; Ramadan, G.; Davies, B.; Margolis, D.A.; Keever-Taylor, C.A., 2007: Stimulation by means of dendritic cells followed by Epstein-Barr virus-transformed B cells as antigen-presenting cells is more efficient than dendritic cells alone in inducing Aspergillus f16-specific cytotoxic T cell responses. Adoptive immunotherapy with in vitro expanded antigen-specific cytotoxic T lymphocytes (CTLs) may be an effective approach to prevent, or even treat, Aspergillus (Asp) infections. Such lines can be generated using monocyte-derived dendritic cells...

McCloskey, M.L.; Curotto de Lafaille, M.A.; Carroll, M.C.; Erlebacher, A., 2011: Acquisition and presentation of follicular dendritic cell-bound antigen by lymph node-resident dendritic cells. Follicular dendritic cells (DCs [FDCs]) are prominent stromal cell constituents of B cell follicles with the remarkable ability to retain complement-fixed antigens on their cell surface for extended periods of time. These retained immune complexes...

He, Yukai; Zhang, Jiying; Mi, Zhibao; Robbins, Paul D.; Falo, Louis D., 2004: Lentiviral Mediated Transduction of Dendritic Cell Progenitors Does Not Alter the Maturation and Antigen Presentation Function of Dendritic Cells. Gene transfer into DCs without skewing their intrinsic function remains a critical challenge for the design of immunotherapies of infection, neoplasms, and autoimmune diseases. We investigated the effect of lentiviral vector on the phenotype and f...