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Antinociceptive mechanism of processed Aconiti tuber; the role of opioid receptors



Antinociceptive mechanism of processed Aconiti tuber; the role of opioid receptors



Natural Medicines 51(4): 368-371



The effect of naloxone, an opiate receptor antagonist, on an antinociceptive action of processed Aconiti tuber (TJ-3022, 1 g/kg, p.o.) was compared with its effect on morphine (4 mg/kg, p.o.) induced antinociception in mice. Naloxone (4 mg/kg, i.p.) attenuated the antinociceptive activity of morphine dramatically, but it antagonized the increase of nociceptive threshold in TJ-3022-treated animals only partially even when naloxone was injected intraperitoneally at a dose of 10 mg/kg. When injected intrathecally, naloxone (2-20 mug/mouse) showed an inhibitory action on the TJ-3022 antinociception in a dose-dependent manner. However, the amount of naloxone required for the inhibition of the antinociceptive response elicited by TJ-3022 was 10-20 times that of morphine. These results suggest that a part of the TJ-3022 antinociceptive activity is mediated by the opioid receptors in the spinal cord, but not related to the mu-receptor subtype.

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Accession: 009770698

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