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Antiproliferative action of interferon-a requires components of T-cell-receptor signalling

Antiproliferative action of interferon-a requires components of T-cell-receptor signalling

Nature 390: 9-32

A study was carried out to determine whether any of the components required for T-cell receptor signaling also associate with the interferon-a (IFN-a) receptor. Signal transduction through both cytokine and lymphocyte antigen receptors shares some common pathways for the initiation of cellular responses, but other signaling components appear to be uniquely coupled to each receptor. Cellular extracts were prepared from either untreated or IFN-a-treated human peripheral blood lymphocytes from normal donors or Jurkat T cells. Assays surprisingly showed that transmission of growth-inhibitory signals by IFN-a in T cells required the expression and association of the tyrosine phosphatase CD45 and the tyrosine kinases Lck and ZAP-70 with the IFN-a-receptor signaling complex.

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Accession: 009770836

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