+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Autonomic modulation of heart rate: pitfalls of nonselective channel blockade



Autonomic modulation of heart rate: pitfalls of nonselective channel blockade



American Journal of Physiology. Heart and Circulatory Physiology 285(6): H Author Reply H2865-H Author Reply H2865



A letter criticizes the recent report by Choate and Feldman (2003;285:H1340-6) on the ionic basis of autonomic modulation of heart rate. The experiments are based on the rationale that use of isolated atrial preparations with intact autonomic innervation allows the contribution of a single ion channel to activity to be inferred from changes in activity caused by ion channel blockers per se. This assumption has contributed to ongoing misunderstandings and controversies in this field of research for decades. Problems with the assumption are discussed. A reply is published.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 009775267

Download citation: RISBibTeXText

PMID: 14613917

DOI: 10.1152/ajpheart.00545.2003


Related references

Effect of beta-blockade on autonomic modulation of heart rate and neurohormonal profile in decompensated heart failure. Annals of Noninvasive Electrocardiology 6(2): 98, 2001

Is heart rate variability a reliable method to assess autonomic modulation in left ventricular dysfunction and heart failure? Assessment of autonomic modulation with heart rate variability. International Journal of Cardiology 67(1): 9, 1998

Is heart rate variability a reliable method to assess autonomic modulation in left ventricular dysfunction and heart failure? Assessment of autonomic modulation with heart rate variability. International Journal of Cardiology 67(1): 9-17, 1998

Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade. Hypertension 59(5): 949-957, 2012

Role of Heart Rate Reduction in the Prevention of Experimental Heart Failure Comparison Between If-Channel Blockade and beta-Receptor Blockade. 2012

Heart rate fluctuations persist in transplanted human hearts following autonomic blockade The role of mechanical stretch in control of heart rate. Journal of Heart & Lung Transplantation 17(1): 103-104, 1998

Heart rate response to sustained hand grip comparison of the effects of cardiac autonomic blockade and diabetic autonomic neuropathy. Clinical Science 56(3): 287-291, 1979

Heart-Rate Response to Sustained Hand Grip: Comparison of the Effects of Cardiac Autonomic Blockade and Diabetic Autonomic Neuropathy. Clinical Science 56(3): 287-291, 1979

Nonselective KATP channel blockade, but not selective mitochondrial KATP channel blockade, limits myocardial oxygen consumption. Circulation 102(18 Suppl.): II 229, 2000

Interrelation of heart rate and autonomic activity in asymptomatic men with unobstructed coronary arteries. Studies with atrial pacing, adrenaline infusion, and autonomic blockade. British Heart Journal 47(1): 19-25, 1982

Effects of low-intensity exercise conditioning on blood pressure, heart rate, and autonomic modulation of heart rate in men and women with hypertension. Biological Research for Nursing 11(2): 129-143, 2009

Pitfalls of assessment of autonomic function by heart rate variability. Journal of Physiological Anthropology 38(1): 3, 2019

Arrhythmia risk stratification in patients with nonischemic dilated cardiomyopathy using markers of autonomic modulation Heart rate turbulence in comparison to heart rate variability and baroreflex sensitivity. Circulation 108(17 Suppl.): IV-324, 2003

Vagal and sympathetic influences on heart rate in heart failure Effects of autonomic blockade and digitalis. Clinical Research 40(3): 748A, 1992

Autonomic blockade and the resting heart rate in man. American Heart Journal 80(4): 469-474, 1970