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Avermektines: Natural variability of the strain producer Streptomyces avermititilis BKM Ac 1301

Avermektines: Natural variability of the strain producer Streptomyces avermititilis BKM Ac 1301

Biotekhnologiya 0(11-12): 21-25

Cultural-morphological, population and biosynthetic characteristics of the strain producer of avermectins S. avermitilis BKM Ac 1301 were studied. High morphological and biosynthetic heterogeneity of the strain was found out. Three colored variants were shown to be stable in the population. A main strain variant has rather low level of avermectin biosynthesis, and produces mostly avermectins of A group with low antiparasite activity and significant amount of antifungal antibiotic analogous of highly lexical oligomycin. The listed characteristics make the strain useless in creation of production of biologicals on the base of avermektines. The strain is promising for selection works at the same time.

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