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BMP-1: resurrection as procollagen C-proteinase



BMP-1: resurrection as procollagen C-proteinase



Science 271: 3



In last week's issue, Kessler et al. reported that bone morphogenetic protein 1 (BMP-1) is a protease but that its substrate is procollagen, not transforming growth factor-b. The researchers demonstrated that BMP-1 shows unexpected similarities to procollagen C-proteinase (PCP), an enzyme that is vital for the proper assembly of collagen within the extracellular matrix. Their study presents a new solution to the old problem of the biological function of BMP-1 and places it directly at a crucial control point of morphogenesis.

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Accession: 009775855

Download citation: RISBibTeXText

PMID: 8560258

DOI: 10.1126/science.271.5248.463


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