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CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae



CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae



American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 280(3): R908-R912



Whigham, Leah D., Ellen B. Cook, James L. Stahl, Ricardo Saban, Dale E. Bjorling, Michael W. Pariza, and Mark E. Cook. CLA reduces antigen-induced histamine and PGE2 release from sensitized guinea pig tracheae. Am J Physiol Regulatory Integrative Comp Physiol 280: R908-R912, 2001.--Conjugated linoleic acid (CLA) has been shown to enhance immune reactions such as lymphocyte blastogenesis and delayed-type hypersensitivity. We investigated the role of CLA in type I (immediate) hypersensitivity, using a guinea pig tracheal superfusion model for measuring antigen-induced airway smooth muscle contraction and inflammatory mediator release. Female Hartley guinea pigs were fed a diet supplemented with 0.25 g corn oil linoleic acid/100 g of diet (control) or 0.25 g CLA/100 g of diet for at least 1 wk before and during active sensitization to ovalbumin antigen. Tracheae from sensitized guinea pigs were suspended in air-filled water-jacketed (37[degree]C) tissue chambers in a superfusion apparatus. Tracheae were superfused with buffer containing antigen, and tissue contraction was recorded. Superfusate was collected at 90-s intervals for evaluation of histamine and PGE2 release. CLA did not affect antigen-induced tracheal contractions when expressed as gram contraction per gram tissue. CLA significantly reduced antigen-induced histamine and PGE2 release. CLA appears to decrease release of some inflammatory mediators during type I hypersensitivity reactions. Reprinted by permission of the publisher.

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Accession: 009783421

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PMID: 11171673


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