Characterization of the specificities of human blood group H gene-specified a1,2- L-fucosyltransferase toward sulfated/sialylated/fucosylated acceptors: evidence for an inverse relationship between a1,2- L-fucosylation of Gal and a1,6- L-fucosylation of asparagine-linked GlcNAc
Chandrasekaran, E.V.; Jain, R.K.; Larsen, R.D.
Biochemistry (American Chemical Society) 35: 14-24
1996
Accession: 009791578
The specificities of a cloned blood group H gene-specified a1,2- L-fucosyltransfersae toward different acceptor structures were characterized to shed light on the assembly of complex structures that bear the H determinant. The acceptor structures were sulfated, sialylated, or fucosylated Galb1,3/4GlcNAab- or Galb1,3GalNAca based. Evidence was found for the existence of an inverse relationship between a1,2- L-fucosylation of Gal and a1,6- L-fucosylation of asparagine-linked GlcNAc.
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