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Demonstration of functional coupling between c-aminobutyric (GABA) synthesis and vesicular GABA transport into synaptic vesicles



Demonstration of functional coupling between c-aminobutyric (GABA) synthesis and vesicular GABA transport into synaptic vesicles



Proceedings of the National Academy of Sciences of the United States of America 100(7): 93-8



The role of L-glutamic acid decarboxylase (GAD) in c-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles was investigated. In the mammalian brain, GAD exists as both membrane-associated and soluble forms. Several observations indicate a functional and structural coupling between the synthesis of GABA by membrane-associated L-glutamic acid decarboxylase (GAD) and its packaging into synaptic vesicles by vesicular GABA transporter. A proposed model links the neuronal stimulation to enhanced synthesis and packaging of GABA synaptic vesicles.

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