+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Differential Effects of Interferon-g on Production of Trypanosome-derived Lymphocyte-triggering Factor by Trypanosoma brucei gambiense and Trypanosoma brucei brucei



Differential Effects of Interferon-g on Production of Trypanosome-derived Lymphocyte-triggering Factor by Trypanosoma brucei gambiense and Trypanosoma brucei brucei



Journal of Parasitology 90(4): 0-5



Trypanosome-derived lymphocyte-triggering factor (TLTF) produced by Trypanosoma brucei brucei stimulates production of interferon-g (IFN-g) by CD8+ T cells, and it is reported that, in turn, IFN-g stimulates proliferation of T. b. brucei. We studied the role of TLTF in trypanosome proliferation using the Wellcome strain (WS) of Trypanosoma brucei gambiense and the IL tat 1.4 strain (IL) of T. b. brucei. Increase in the number of WS in infected rats is more rapid than IL and corresponds with comparatively higher levels of IFN-g. Production of IFN-g, as measured by protein and messenger RNA (mRNA) levels, was maintained by splenocytes from WS-infected rats, whereas levels decreased in IL-infected rats, accompanied by prolongation of infection. Expression of TLTF mRNA by in vitro-cultured WS was promoted in a dose-dependent fashion by addition of recombinant rat IFN-g at all concentrations tested. The addition of lower concentrations of IFN-g to cultured IL increased expression of TLTF mRNA, whereas, in contrast to WS, addition of 100 and 1,000 U/ml IFN-g decreased expression of TLTF by IL. These results show that unlike WS, elevated IFN-g concentrations lead to decreased TLTF production by IL. It is believed that decreased TLTF production in IL-infected rats leads to lowered IFN-g production, thereby slowing IL proliferation. Reprinted by permission of the publisher.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 009817427

Download citation: RISBibTeXText


Related references

Differential Effects of Interferon- on Production of Trypanosome-Derived Lymphocyte-Triggering Factor by Trypanosoma brucei Gambiense and Trypanosoma brucei brucei. The Journal of Parasitology 90(4): 740-745, 2004

Differential effects of interferon- on production of trypanosome-derived lymphocyte-triggering factor by Trypanosoma brucei gambiense and Trypanosoma brucei brucei. Journal of Parasitology ust; 90(4): 740-745, 2004

Differential effects of interferon-gamma on production of trypanosome-derived lymphocyte-triggering factor by Trypanosoma brucei gambiense and Trypanosoma brucei brucei. Journal of Parasitology 90(4): 740-745, 2004

Quantitation of genetic differences between trypanosoma brucei gambiense trypanosoma brucei rhodesiense and trypanosoma brucei brucei by restriction enzyme analysis of kinetoplast dna. Molecular & Biochemical Parasitology 3(2): 117-131, 1981

Measure of molecular diversity within the Trypanosoma brucei subspecies Trypanosoma brucei brucei and Trypanosoma brucei gambiense as revealed by genotypic characterization. Experimental Parasitology 99(3): 123-131, 2001

In vitro cultivation of bloodstream forms of trypanosoma brucei brucei trypanosoma brucei rhodesiense and trypanosoma brucei gambiense. Journal of Protozoology 28(4): 470-479, 1981

Differential Effects Of Trypanosoma Brucei Gambiense And Trypanosoma Brucei Brucei On Rat Macrophages. The Journal of Parasitology 97(1): 48-54, 2011

Differential effects of Trypanosoma brucei gambiense and Trypanosoma brucei brucei on rat macrophages. Journal of Parasitology 97(1): 48-54, 2011

Trypanosoma brucei brucei and Trypanosoma brucei gambiense: stage specific differences in wheat germ agglutinin binding and in endoglycosidase H sensitivity of glycoprotein oligosaccharides. Experimental Parasitology 641: 104-110, 1987

Human serum resistance of metacyclic forms of Trypanosoma brucei brucei, T. brucei rhodesiense and T. brucei gambiense. Parasitology Research 73(3): 218-223, 1987

Trypanosoma brucei brucei, T. brucei gambiense, and T. brucei rhodesiense: common glycoproteins and glycoprotein oligosaccharide heterogeneity identified by lectin affinity blotting and endoglycosidase H treatment. Experimental Parasitology 63(1): 32-41, 1987

Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. Experimental Parasitology 75(3): 353-360, 1992

The genome and the antigen gene repertoire of trypanosoma brucei gambiense are smaller than those of trypanosoma brucei brucei. Molecular & Biochemical Parasitology 26(3): 247-256, 1987

T cell activation by a Trypanosoma brucei brucei-derived lymphocyte triggering factor is dependent on tyrosine protein kinases but not on protein kinase C and A. European Journal of Immunology 23(7): 1535-1539, 1993

The origins of the trypanosome genome strains Trypanosoma brucei brucei TREU 927, T. b. gambiense DAL 972, T. vivax Y486 and T. congolense IL3000. Parasites & Vectors 5: 71-71, 2012