Effect of highly selective vagotomy on gastric emptying, gastric acid secretion, and gastrin release: an early postoperative study in duodenal ulcer patients
Lukasiewicz, S.; Jonderko, K.
Tokai Journal of Experimental and Clinical Medicine 18(1-2): 29-37
In 12 duodenal ulcer patients, gastric emptying (GE) of a radiolabelled solid meal, gastric acid secretion, and gastrin release were examined before and during the early postoperative period (median 13.5 days) after a highly selective vagotomy (HSV). HSV significantly delayed GE; the median slope of GE curves (K) decreased from 11.86 to 6.52 min-1 times 10-3 (p lt 0.01). A significant inhibition of the late phase of GE was reflected by a diminution of the curve shape parameter (S) from a median of 1.41 to 0.98 (p lt 0.02). A profound impairment of GE after HSV was found in 4 of 12 patients (33%). HSV resulted in a 49% decrease in the basal acid output (6.9 +- 1.0 before to 3.5 +- 1.0 mmol cntdot h-1 after HSV, and a 56% reduction in the pentagastrin-stimulated gastric acid secretion (31.1 +- 5.1 before vs 13.8 +- 2.4 mmol cntdot h-1 after HSV (p lt 0.01). A significant increase in both the fasted serum gastrin (38.9 +- 3.7 to 66.9 +- 8.4 ng cntdot l-1, p lt 0.05) and the meal-stimulated gastrin release (AUC-0-120: 7179 +- 440 to 11158 +- 1062 ng cntdot l-1 min, p lt 0.05) was observed after HSV.